EPO and TMBIM3/GRINA Promote the Activation of the Adaptive Arm and Counteract the Terminal Arm of the Unfolded Protein Response after Murine Transient Cerebral Ischemia

EPO and TMBIM3/GRINA Promote the Activation of the Adaptive Arm and Counteract the Terminal Arm of the Unfolded Protein Response after Murine Transient Cerebral Ischemia

Ischemic stroke is known to cause the accumulation of misfolded proteins and loss of calcium homeostasis leading to impairment of endoplasmic reticulum (ER) function. The unfolded protein response (UPR) is an ER-located and cytoprotective pathway that aims to resolve ER stress. Transmembrane BAX inh...

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Bibliographic Details
Main Authors: Pardes Habib, Ann-Sophie Stamm, Joerg B. Schulz, Arno Reich, Alexander Slowik, Sandro Capellmann, Michael Huber, Thomas Wilhelm
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
upr
gsk-2606414
stf-083010
perk
ire1α
stroke
grina
neuroprotection
epo
Online Access:https://www.mdpi.com/1422-0067/20/21/5421

Internet

https://www.mdpi.com/1422-0067/20/21/5421

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