Rif1 Controls DNA Replication Timing in Yeast through the PP1 Phosphatase Glc7

Rif1 Controls DNA Replication Timing in Yeast through the PP1 Phosphatase Glc7

The Rif1 protein, originally identified as a telomere-binding factor in yeast, has recently been implicated in DNA replication control from yeast to metazoans. Here, we show that budding yeast Rif1 protein inhibits activation of prereplication complexes (pre-RCs). This inhibitory function requires t...

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Bibliographic Details
Main Authors: Stefano Mattarocci, Maksym Shyian, Laure Lemmens, Pascal Damay, Dogus Murat Altintas, Tianlai Shi, Clinton R. Bartholomew, Nicolas H. Thomä, Christopher F.J. Hardy, David Shore
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714001880

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http://www.sciencedirect.com/science/article/pii/S2211124714001880

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