Abnormal Rat Cortical Development Induced by Ventricular Injection of rHMGB1 Mimics the Pathophysiology of Human Cortical Dysplasia

Abnormal Rat Cortical Development Induced by Ventricular Injection of rHMGB1 Mimics the Pathophysiology of Human Cortical Dysplasia

Cortical dysplasia (CD) is a common cause of drug-resistant epilepsy. Increasing studies have implicated innate immunity in CD with epilepsy. However, it is unclear whether innate immune factors induce epileptogenic CD. Here, we injected recombinant human high mobility group box 1 (rHMGB1) into embr...

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Bibliographic Details
Main Authors: Xiaolin Yang, Xiaoqing Zhang, Yuanshi Ma, Zhongke Wang, Kaixuan Huang, Guolong Liu, Kaifeng Shen, Gang Zhu, Tingting Wang, Shengqing Lv, Chunqing Zhang, Hui Yang, Shiyong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cortical dysplasia
high-mobility group box 1
spike wave
innate immune inflammation
epilepsy
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.634405/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.634405/full

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