The effect of etidronate on choroidal neovascular activity in patients with pseudoxanthoma elasticum.
<h4>Aim</h4>To assess the effect of the bisphosphonate etidronate on choroidal neovascular (CNV) activity in patients with pseudoxanthoma elasticum (PXE).<h4>Methods</h4>This is an ancillary study in a single center, randomized, double-blind placebo-controlled trial (RCT) in...
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doaj-eaa93e46028e44ce882f3b2312b9f58c2021-03-04T11:09:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011510e024097010.1371/journal.pone.0240970The effect of etidronate on choroidal neovascular activity in patients with pseudoxanthoma elasticum.Sara RisseeuwRedmer van LeeuwenSaskia M ImhofPim A de JongWillem P Th M MaliWilko SpieringJeannette Ossewaarde-van Norel<h4>Aim</h4>To assess the effect of the bisphosphonate etidronate on choroidal neovascular (CNV) activity in patients with pseudoxanthoma elasticum (PXE).<h4>Methods</h4>This is an ancillary study in a single center, randomized, double-blind placebo-controlled trial (RCT) in which 74 patients with PXE were assigned to either one-year etidronate or placebo treatment. Spectral domain optical coherence tomography (SD-OCT) imaging and color fundus photography were performed every three months for one year and were systematically assessed on signs of CNV activity.<h4>Results</h4>In the etidronate group, 11 (30%) of the patients had CNV activity at baseline, compared to 25 (67%) of the patients in the placebo group (P = 0.005). The proportion of eyes with CNV activity during the study ranged from 18-33% in the etidronate group and 42-56% in the placebo group and no significant difference in improvement or worsening of CNV activity was found (P = 0.168). Using a generalized mixed model for repeated measures, there was a protective effect of etidronate in crude analysis (RR 0.86, 95% CI 0.75-0.98) that disappeared when adjusting for baseline CNV activity (RR 0.97, 95% CI 0.84-1.13).<h4>Conclusion</h4>In this post-hoc RCT analysis we did not observe a protecting or deteriorating effect of etidronate on CNV activity in patients with PXE after adjustment for baseline CNV.https://doi.org/10.1371/journal.pone.0240970 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sara Risseeuw Redmer van Leeuwen Saskia M Imhof Pim A de Jong Willem P Th M Mali Wilko Spiering Jeannette Ossewaarde-van Norel |
spellingShingle |
Sara Risseeuw Redmer van Leeuwen Saskia M Imhof Pim A de Jong Willem P Th M Mali Wilko Spiering Jeannette Ossewaarde-van Norel The effect of etidronate on choroidal neovascular activity in patients with pseudoxanthoma elasticum. PLoS ONE |
author_facet |
Sara Risseeuw Redmer van Leeuwen Saskia M Imhof Pim A de Jong Willem P Th M Mali Wilko Spiering Jeannette Ossewaarde-van Norel |
author_sort |
Sara Risseeuw |
title |
The effect of etidronate on choroidal neovascular activity in patients with pseudoxanthoma elasticum. |
title_short |
The effect of etidronate on choroidal neovascular activity in patients with pseudoxanthoma elasticum. |
title_full |
The effect of etidronate on choroidal neovascular activity in patients with pseudoxanthoma elasticum. |
title_fullStr |
The effect of etidronate on choroidal neovascular activity in patients with pseudoxanthoma elasticum. |
title_full_unstemmed |
The effect of etidronate on choroidal neovascular activity in patients with pseudoxanthoma elasticum. |
title_sort |
effect of etidronate on choroidal neovascular activity in patients with pseudoxanthoma elasticum. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2020-01-01 |
description |
<h4>Aim</h4>To assess the effect of the bisphosphonate etidronate on choroidal neovascular (CNV) activity in patients with pseudoxanthoma elasticum (PXE).<h4>Methods</h4>This is an ancillary study in a single center, randomized, double-blind placebo-controlled trial (RCT) in which 74 patients with PXE were assigned to either one-year etidronate or placebo treatment. Spectral domain optical coherence tomography (SD-OCT) imaging and color fundus photography were performed every three months for one year and were systematically assessed on signs of CNV activity.<h4>Results</h4>In the etidronate group, 11 (30%) of the patients had CNV activity at baseline, compared to 25 (67%) of the patients in the placebo group (P = 0.005). The proportion of eyes with CNV activity during the study ranged from 18-33% in the etidronate group and 42-56% in the placebo group and no significant difference in improvement or worsening of CNV activity was found (P = 0.168). Using a generalized mixed model for repeated measures, there was a protective effect of etidronate in crude analysis (RR 0.86, 95% CI 0.75-0.98) that disappeared when adjusting for baseline CNV activity (RR 0.97, 95% CI 0.84-1.13).<h4>Conclusion</h4>In this post-hoc RCT analysis we did not observe a protecting or deteriorating effect of etidronate on CNV activity in patients with PXE after adjustment for baseline CNV. |
url |
https://doi.org/10.1371/journal.pone.0240970 |
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