UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin

UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin

The ubiquitin proteasome system (UPS) is the main player of skeletal muscle wasting, a common characteristic of many diseases (cancer, etc.) that negatively impacts treatment and life prognosis. Within the UPS, the E3 ligase MuRF1/TRIM63 targets for degradation several myofibrillar proteins, includi...

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Bibliographic Details
Main Authors: Dulce Peris-Moreno, Mélodie Malige, Agnès Claustre, Andrea Armani, Cécile Coudy-Gandilhon, Christiane Deval, Daniel Béchet, Pierre Fafournoux, Marco Sandri, Lydie Combaret, Daniel Taillandier, Cécile Polge
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
MuRF1/TRIM63
skeletal muscle atrophy
glucocorticoids
UBE2L3/UbcH7
alpha-actin
myosin
Online Access:https://www.mdpi.com/2073-4409/10/8/1974

Internet

https://www.mdpi.com/2073-4409/10/8/1974

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