Tripartite assembly of RND multidrug efflux pumps

Tripartite assembly of RND multidrug efflux pumps

Tripartite efflux systems consist of inner membrane, outer membrane and periplasmic components. Here, Daury et al. reconstitute native versions of RND transporters in nanodiscs and present projection structures emphasizing the role of the periplasmic adaptor in linking the inner and outer membrane p...

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Main Authors: Laetitia Daury, François Orange, Jean-Christophe Taveau, Alice Verchère, Laura Monlezun, Céline Gounou, Ravi K. R. Marreddy, Martin Picard, Isabelle Broutin, Klaas M. Pos, Olivier Lambert
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10731
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spelling doaj-eba793de8123457e92c40e3142a2ad4f2021-05-11T10:51:04ZengNature Publishing GroupNature Communications2041-17232016-02-01711810.1038/ncomms10731Tripartite assembly of RND multidrug efflux pumpsLaetitia Daury0François Orange1Jean-Christophe Taveau2Alice Verchère3Laura Monlezun4Céline Gounou5Ravi K. R. Marreddy6Martin Picard7Isabelle Broutin8Klaas M. Pos9Olivier Lambert10Université de Bordeaux, CBMN UMR 5248, Bordeaux INP, IECBUniversité de Bordeaux, CBMN UMR 5248, Bordeaux INP, IECBUniversité de Bordeaux, CBMN UMR 5248, Bordeaux INP, IECBLaboratoire de Cristallographie et RMN Biologiques, UMR 8015, CNRS, Université Paris Descartes, Faculté de PharmacieLaboratoire de Cristallographie et RMN Biologiques, UMR 8015, CNRS, Université Paris Descartes, Faculté de PharmacieUniversité de Bordeaux, CBMN UMR 5248, Bordeaux INP, IECBInstitute of Biochemistry, Goethe-University FrankfurtLaboratoire de Cristallographie et RMN Biologiques, UMR 8015, CNRS, Université Paris Descartes, Faculté de PharmacieLaboratoire de Cristallographie et RMN Biologiques, UMR 8015, CNRS, Université Paris Descartes, Faculté de PharmacieInstitute of Biochemistry, Goethe-University FrankfurtUniversité de Bordeaux, CBMN UMR 5248, Bordeaux INP, IECBTripartite efflux systems consist of inner membrane, outer membrane and periplasmic components. Here, Daury et al. reconstitute native versions of RND transporters in nanodiscs and present projection structures emphasizing the role of the periplasmic adaptor in linking the inner and outer membrane proteins.https://doi.org/10.1038/ncomms10731
collection DOAJ
language English
format Article
sources DOAJ
author Laetitia Daury
François Orange
Jean-Christophe Taveau
Alice Verchère
Laura Monlezun
Céline Gounou
Ravi K. R. Marreddy
Martin Picard
Isabelle Broutin
Klaas M. Pos
Olivier Lambert
spellingShingle Laetitia Daury
François Orange
Jean-Christophe Taveau
Alice Verchère
Laura Monlezun
Céline Gounou
Ravi K. R. Marreddy
Martin Picard
Isabelle Broutin
Klaas M. Pos
Olivier Lambert
Tripartite assembly of RND multidrug efflux pumps
Nature Communications
author_facet Laetitia Daury
François Orange
Jean-Christophe Taveau
Alice Verchère
Laura Monlezun
Céline Gounou
Ravi K. R. Marreddy
Martin Picard
Isabelle Broutin
Klaas M. Pos
Olivier Lambert
author_sort Laetitia Daury
title Tripartite assembly of RND multidrug efflux pumps
title_short Tripartite assembly of RND multidrug efflux pumps
title_full Tripartite assembly of RND multidrug efflux pumps
title_fullStr Tripartite assembly of RND multidrug efflux pumps
title_full_unstemmed Tripartite assembly of RND multidrug efflux pumps
title_sort tripartite assembly of rnd multidrug efflux pumps
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-02-01
description Tripartite efflux systems consist of inner membrane, outer membrane and periplasmic components. Here, Daury et al. reconstitute native versions of RND transporters in nanodiscs and present projection structures emphasizing the role of the periplasmic adaptor in linking the inner and outer membrane proteins.
url https://doi.org/10.1038/ncomms10731
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