Uncoupling of Elastin Complex Receptor during In Vitro Aging Is Related to Modifications in Its Intrinsic Sialidase Activity and the Subsequent Lactosylceramide Production.

Uncoupling of Elastin Complex Receptor during In Vitro Aging Is Related to Modifications in Its Intrinsic Sialidase Activity and the Subsequent Lactosylceramide Production.

Degradation of elastin leads to the production of elastin-derived peptides (EDP), which exhibit several biological effects, such as cell proliferation or protease secretion. Binding of EDP on the elastin receptor complex (ERC) triggers lactosylceramide (LacCer) production and ERK1/2 activation follo...

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Main Authors: Amandine Scandolera, Fanja Rabenoelina, Carine Chaintreuil, Anthony Rusciani, Pascal Maurice, Sébastien Blaise, Béatrice Romier-Crouzet, Hassan El Btaouri, Laurent Martiny, Laurent Debelle, Laurent Duca
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4473072?pdf=render

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http://europepmc.org/articles/PMC4473072?pdf=render

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