Low-grade peripheral inflammation affects brain pathology in the App NL-G-F mouse model of Alzheimer’s disease

Low-grade peripheral inflammation affects brain pathology in the App NL-G-F mouse model of Alzheimer’s disease

Abstract Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid β (Aβ) and neurofibrillary tangles. The last decade, it became increasingly clear that neuroinflammation plays a key role in both the initiation and progression of AD. Moreover, also...

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Bibliographic Details
Main Authors: Junhua Xie, Nina Gorlé, Charysse Vandendriessche, Griet Van Imschoot, Elien Van Wonterghem, Caroline Van Cauwenberghe, Eef Parthoens, Evelien Van Hamme, Saskia Lippens, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Acta Neuropathologica Communications
Subjects:
Low-grade peripheral inflammation
 Brain barriers
Choroid plexus
 Blood-CSF barrier
Alzheimer's disease
Online Access:https://doi.org/10.1186/s40478-021-01253-z

Internet

https://doi.org/10.1186/s40478-021-01253-z

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