Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers
<p><strong>Introduction: </strong>Investigate whether polymorphism in the promoter region encoding leptin and leptin receptor gene, in normal weight individuals, affects hormonal and appetite responses to peanuts.</p><p><strong>Materials and methods:</strong>...
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Academia Española de Nutrición y Dietética
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doaj-ec594cd4739c4804acf334c10d87441b2020-12-02T06:26:47ZengAcademia Española de Nutrición y DietéticaRevista Española de Nutrición Humana y Dietética2173-12922174-51452014-05-011613910.14306/renhyd.16.1.10067Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteersSandra Bragança Coelho0Patrícia G Cardoso1Josefina Bressan2Neuza MB Costa3Rita CG Alfenas4Universidade Federal de Lavras, Minas GeraisUniversidade Federal de Lavras, Minas GeraisUniversidade Federal de Viçosa, Viçosa, Minas GeraisDepartamento de Nutrição, Universidade Federal do Espírito Santo, AlegreUniversidade Federal de Viçosa, Viçosa, Minas Gerais<p><strong>Introduction: </strong>Investigate whether polymorphism in the promoter region encoding leptin and leptin receptor gene, in normal weight individuals, affects hormonal and appetite responses to peanuts.</p><p><strong>Materials and methods:</strong> Appetite, anthropometric indices, body composition, physical activity, dietary intake and leptin, ghrelin and insulin levels were monitored. Polymorphism analyses were also carried out.</p><p><strong>Results:</strong> None of the treatments led to statistical differences in the analyzed hormones. No polymorphism was found for leptin receptor gene, while for leptin gene, 50% of the volunteers presented one polymorphic allele and 13% presented both polymorphic alleles. These last ones presented lower body fat mass, leptin and ghrelin plasma concentrations, and fullness rates. They also presented higher hunger, desire to eat, and desire to eat sweet and salty foods.</p><p><strong>Conclusions:</strong> Peanut did not affect appetite and presented no different hormonal responses, compared to other foods studied. Polymorphic allele carriers in both alleles presented higher probability to develop obesity. However, the magnitude of this probability could not be measured.</p>http://renhyd.org/index.php/renhyd/article/view/100PolimorfismoGen de la leptinaLeptinaGrelinaFalta de apetito |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sandra Bragança Coelho Patrícia G Cardoso Josefina Bressan Neuza MB Costa Rita CG Alfenas |
spellingShingle |
Sandra Bragança Coelho Patrícia G Cardoso Josefina Bressan Neuza MB Costa Rita CG Alfenas Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers Revista Española de Nutrición Humana y Dietética Polimorfismo Gen de la leptina Leptina Grelina Falta de apetito |
author_facet |
Sandra Bragança Coelho Patrícia G Cardoso Josefina Bressan Neuza MB Costa Rita CG Alfenas |
author_sort |
Sandra Bragança Coelho |
title |
Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers |
title_short |
Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers |
title_full |
Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers |
title_fullStr |
Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers |
title_full_unstemmed |
Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers |
title_sort |
leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers |
publisher |
Academia Española de Nutrición y Dietética |
series |
Revista Española de Nutrición Humana y Dietética |
issn |
2173-1292 2174-5145 |
publishDate |
2014-05-01 |
description |
<p><strong>Introduction: </strong>Investigate whether polymorphism in the promoter region encoding leptin and leptin receptor gene, in normal weight individuals, affects hormonal and appetite responses to peanuts.</p><p><strong>Materials and methods:</strong> Appetite, anthropometric indices, body composition, physical activity, dietary intake and leptin, ghrelin and insulin levels were monitored. Polymorphism analyses were also carried out.</p><p><strong>Results:</strong> None of the treatments led to statistical differences in the analyzed hormones. No polymorphism was found for leptin receptor gene, while for leptin gene, 50% of the volunteers presented one polymorphic allele and 13% presented both polymorphic alleles. These last ones presented lower body fat mass, leptin and ghrelin plasma concentrations, and fullness rates. They also presented higher hunger, desire to eat, and desire to eat sweet and salty foods.</p><p><strong>Conclusions:</strong> Peanut did not affect appetite and presented no different hormonal responses, compared to other foods studied. Polymorphic allele carriers in both alleles presented higher probability to develop obesity. However, the magnitude of this probability could not be measured.</p> |
topic |
Polimorfismo Gen de la leptina Leptina Grelina Falta de apetito |
url |
http://renhyd.org/index.php/renhyd/article/view/100 |
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