Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases

Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases

Misfolded proteins are the main common feature of neurodegenerative diseases, thereby, normal proteostasis is an important mechanism to regulate the neural survival and the central nervous system functionality. The ubiquitin-proteasome system (UPS) is a non-lysosomal proteolytic pathway involved in...

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Bibliographic Details
Main Authors: Saeideh Momtaz, Zahra Memariani, Fardous F. El-Senduny, Nima Sanadgol, Fereshteh Golab, Majid Katebi, Amir Hossein Abdolghaffari, Mohammad Hosein Farzaei, Mohammad Abdollahi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
ubiquitin-proteasome pathway
neurodegenerative diseases
Alzheimer's disease
Parkinson's disease
Huntington disease
Amyotrophic lateral sclerosis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00361/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00361/full

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