Topical N-Acetylcysteine Accelerates Wound Healing in Vitro and in Vivo via the PKC/Stat3 Pathway

Topical N-Acetylcysteine Accelerates Wound Healing in Vitro and in Vivo via the PKC/Stat3 Pathway

N-Acetylcysteine (Nac) is an antioxidant administered in both oral and injectable forms. In this study, we used Nac topically to treat burn wounds in vitro and in vivo to investigate mechanisms of action. In vitro, we monitored glutathione levels, cell proliferation, migration, scratch-wound healing...

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Bibliographic Details
Main Authors: Min-Ling Tsai, Hui-Pei Huang, Jeng-Dong Hsu, Yung-Rung Lai, Yu-Ping Hsiao, Fung-Jou Lu, Horng-Rong Chang
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:International Journal of Molecular Sciences
Subjects:
N-acetylcysteine
wound healing
glutathione
MMP-1
PKC
Stat3
Online Access:http://www.mdpi.com/1422-0067/15/5/7563

Internet

http://www.mdpi.com/1422-0067/15/5/7563

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