ApoE4 Astrocytes Secrete Basement Membranes Rich in Fibronectin and Poor in Laminin Compared to ApoE3 Astrocytes

The accumulation of amyloid-β (Aβ) in the walls of capillaries and arteries as cerebral amyloid angiopathy (CAA) is part of the small vessel disease spectrum, related to a failure of elimination of Aβ from the brain. Aβ is eliminated along basement membranes in walls of cerebral capillaries and arte...

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Bibliographic Details
Main Authors: Abby Keable, Ronan O’Neill, Matthew MacGregor Sharp, Maureen Gatherer, Ho Ming Yuen, David Annandale Johnston, Roy Oliver Weller, Roxana Octavia Carare
Format: Article
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Online Access:https://www.mdpi.com/1422-0067/21/12/4371