Daurinol Attenuates Autoimmune Arthritis via Stabilization of Nrp1–PTEN–Foxp3 Signaling in Regulatory T Cells

Daurinol Attenuates Autoimmune Arthritis via Stabilization of Nrp1–PTEN–Foxp3 Signaling in Regulatory T Cells

Optimizing Treg function and improving Treg stability are attractive treatment strategies for treating autoimmune rheumatoid arthritis (RA). However, the limited number of circulating Tregs and questions about the functional stability of in vitro-expanded Tregs are potential limitations of Treg-base...

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Bibliographic Details
Main Authors: Min-Jung Park, Su-Jin Moon, Eun-Jung Lee, Eun-Kyung Kim, Jin-Ah Baek, Se-Young Kim, Kyung Ah Jung, Seung Hoon Lee, Jeong Won Choi, Da-Som Kim, Jun-Ki Min, Sung-Hwan Park, Dongyun Shin, Mi-La Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
daurinol
regulatory T cells
stability
FOXP3 hypomethylation
rheumatoid arthritis
neuropilin 1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01526/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01526/full

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