Next‐Generation Sequencing‐Based RiboMethSeq  Protocol for Analysis of tRNA 2′‐O‐Methylation

Next‐Generation Sequencing‐Based RiboMethSeq  Protocol for Analysis of tRNA 2′‐O‐Methylation

Analysis of RNA modifications by traditional physico‐chemical approaches is labor  intensive,  requires  substantial  amounts  of  input  material  and  only  allows  site‐by‐site  measurements.  The  recent  development  of  qualitative  and  quantitative  approaches  based  on   next‐generation se...

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Bibliographic Details
Main Authors: Virginie Marchand, Florian Pichot, Kathrin Thüring, Lilia Ayadi, Isabel Freund, Alexander Dalpke, Mark Helm, Yuri Motorin
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Biomolecules
Subjects:
tRNA
 2′‐O‐methylation
 RiboMethSeq
 high‐throughput sequencing
 deleted strain
  TrmH
 TRM3
Online Access:http://www.mdpi.com/2218-273X/7/1/13

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