The Newcastle Pediatric Mitochondrial Disease Scale: translation and cultural adaptation for use in Brazil

ABSTRACT Objective The aim of this study was to translate and adapt the Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) to Portuguese for use in Brazil. Methods The scale was applied in 20 pediatric patients with mitochondrial disease, in three groups: myopathy (n = 4); Leigh syndrome (...

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Main Authors: Gabriela Palhares Campolina-Sampaio, Laura Maria de Lima Belizário Facury Lasmar, Beatriz Silva Vilela Ribeiro, Juliana Gurgel Giannetti
Format: Article
Language:English
Published: Academia Brasileira de Neurologia (ABNEURO)
Series:Arquivos de Neuro-Psiquiatria
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001100909&lng=en&tlng=en
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spelling doaj-edfd006dc0874bbdbd983b4ffd96c7182020-11-24T22:11:33ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-4227741190991310.1590/0004-282x20160137S0004-282X2016001100909The Newcastle Pediatric Mitochondrial Disease Scale: translation and cultural adaptation for use in BrazilGabriela Palhares Campolina-SampaioLaura Maria de Lima Belizário Facury LasmarBeatriz Silva Vilela RibeiroJuliana Gurgel GiannettiABSTRACT Objective The aim of this study was to translate and adapt the Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) to Portuguese for use in Brazil. Methods The scale was applied in 20 pediatric patients with mitochondrial disease, in three groups: myopathy (n = 4); Leigh syndrome (n = 8); and encephalomyopathy (n = 8). Scores were obtained for the various dimensions of the NPMDS, and comparisons were drawn between the groups. Results There was a statistically significant difference between the myopathy group and the Leigh syndrome group (p = 0.0085), as well as between the myopathy and encephalomyopathy groups (p = 0.01). Conclusions The translation of the NPMDS, and its adaptation to the socioeconomic and cultural conditions in Brazil, make the NPMDS score useful as an additional parameter in the evaluation and monitoring of pediatric patients with MD in Brazil.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001100909&lng=en&tlng=enNewcastle diseasemitochondrial diseases, mitochondrial myopathiesmitochondrial encephalomyopathiesLeigh disease
collection DOAJ
language English
format Article
sources DOAJ
author Gabriela Palhares Campolina-Sampaio
Laura Maria de Lima Belizário Facury Lasmar
Beatriz Silva Vilela Ribeiro
Juliana Gurgel Giannetti
spellingShingle Gabriela Palhares Campolina-Sampaio
Laura Maria de Lima Belizário Facury Lasmar
Beatriz Silva Vilela Ribeiro
Juliana Gurgel Giannetti
The Newcastle Pediatric Mitochondrial Disease Scale: translation and cultural adaptation for use in Brazil
Arquivos de Neuro-Psiquiatria
Newcastle disease
mitochondrial diseases, mitochondrial myopathies
mitochondrial encephalomyopathies
Leigh disease
author_facet Gabriela Palhares Campolina-Sampaio
Laura Maria de Lima Belizário Facury Lasmar
Beatriz Silva Vilela Ribeiro
Juliana Gurgel Giannetti
author_sort Gabriela Palhares Campolina-Sampaio
title The Newcastle Pediatric Mitochondrial Disease Scale: translation and cultural adaptation for use in Brazil
title_short The Newcastle Pediatric Mitochondrial Disease Scale: translation and cultural adaptation for use in Brazil
title_full The Newcastle Pediatric Mitochondrial Disease Scale: translation and cultural adaptation for use in Brazil
title_fullStr The Newcastle Pediatric Mitochondrial Disease Scale: translation and cultural adaptation for use in Brazil
title_full_unstemmed The Newcastle Pediatric Mitochondrial Disease Scale: translation and cultural adaptation for use in Brazil
title_sort newcastle pediatric mitochondrial disease scale: translation and cultural adaptation for use in brazil
publisher Academia Brasileira de Neurologia (ABNEURO)
series Arquivos de Neuro-Psiquiatria
issn 1678-4227
description ABSTRACT Objective The aim of this study was to translate and adapt the Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) to Portuguese for use in Brazil. Methods The scale was applied in 20 pediatric patients with mitochondrial disease, in three groups: myopathy (n = 4); Leigh syndrome (n = 8); and encephalomyopathy (n = 8). Scores were obtained for the various dimensions of the NPMDS, and comparisons were drawn between the groups. Results There was a statistically significant difference between the myopathy group and the Leigh syndrome group (p = 0.0085), as well as between the myopathy and encephalomyopathy groups (p = 0.01). Conclusions The translation of the NPMDS, and its adaptation to the socioeconomic and cultural conditions in Brazil, make the NPMDS score useful as an additional parameter in the evaluation and monitoring of pediatric patients with MD in Brazil.
topic Newcastle disease
mitochondrial diseases, mitochondrial myopathies
mitochondrial encephalomyopathies
Leigh disease
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001100909&lng=en&tlng=en
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