Weight Change and Cardiometabolic Outcomes in Postpartum Women with History of Gestational Diabetes

Weight gain after childbirth is a significant risk factor for type 2 diabetes (T2DM) development after gestational diabetes mellitus (GDM). The level of weight loss achieved in diabetes prevention programs for women after GDM is often low but its effects on the cardiometabolic risk are not known. In...

Full description

Bibliographic Details
Main Authors: Siew Lim, Vincent L. Versace, Sharleen O’Reilly, Edward Janus, James Dunbar
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Nutrients
Subjects:
Online Access:https://www.mdpi.com/2072-6643/11/4/922
id doaj-ee3c87b0567a488191dc028eef5afedf
record_format Article
spelling doaj-ee3c87b0567a488191dc028eef5afedf2020-11-25T00:30:04ZengMDPI AGNutrients2072-66432019-04-0111492210.3390/nu11040922nu11040922Weight Change and Cardiometabolic Outcomes in Postpartum Women with History of Gestational DiabetesSiew Lim0Vincent L. Versace1Sharleen O’Reilly2Edward Janus3James Dunbar4Monash Centre for Health Research and Implementation, Monash University, 3168 Clayton, AustraliaDeakin Rural Health, School of Medicine, Deakin University, 3217 Geelong, AustraliaInstitute of Food and Health, School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, IrelandGeneral Internal Medicine Unit, Western Health and Department of Medicine, Melbourne Medical School—Western Precinct, University of Melbourne, 3010 Melbourne, AustraliaDeakin Rural Health, School of Medicine, Deakin University, 3217 Geelong, AustraliaWeight gain after childbirth is a significant risk factor for type 2 diabetes (T2DM) development after gestational diabetes mellitus (GDM). The level of weight loss achieved in diabetes prevention programs for women after GDM is often low but its effects on the cardiometabolic risk are not known. In a secondary analysis of a diabetes prevention program in postpartum women with history of gestational diabetes, we evaluated the effect of weight change on the cardiometabolic outcomes at 1-year follow-up. Of the 284 women randomized to the intervention arm, 206 with the final outcome measurements were included in the analyses. Participants were categorized into weight loss (&gt;2 kg, <i>n</i> = 74), weight stable (&#177;2 kg, <i>n</i> = 74) or weight gain (&gt;2 kg, <i>n</i> = 58) groups. The weight loss group had significantly greater decrease in glycated hemoglobin (HbA1c) than the weight gain group (&#8722;0.1 + 0.4% vs. 0 + 0.4%, <i>p</i> = 0.049). The weight loss group had significantly greater decrease in total cholesterol and low-density lipoprotein cholesterol cholesterol than the other two groups (<i>p</i> &lt; 0.05). The weight gain group had significantly greater increase in triglyceride and triglyceride:high-density lipoprotein cholesterol ratio compare with the other groups (<i>p</i> &lt; 0.01). Overall, a small amount of weight loss and prevention of further weight gain was beneficial to the cardiometabolic outcomes of postpartum women after GDM.https://www.mdpi.com/2072-6643/11/4/922gestational diabetesdiabetes prevention programweight lossweight gainpostpartum
collection DOAJ
language English
format Article
sources DOAJ
author Siew Lim
Vincent L. Versace
Sharleen O’Reilly
Edward Janus
James Dunbar
spellingShingle Siew Lim
Vincent L. Versace
Sharleen O’Reilly
Edward Janus
James Dunbar
Weight Change and Cardiometabolic Outcomes in Postpartum Women with History of Gestational Diabetes
Nutrients
gestational diabetes
diabetes prevention program
weight loss
weight gain
postpartum
author_facet Siew Lim
Vincent L. Versace
Sharleen O’Reilly
Edward Janus
James Dunbar
author_sort Siew Lim
title Weight Change and Cardiometabolic Outcomes in Postpartum Women with History of Gestational Diabetes
title_short Weight Change and Cardiometabolic Outcomes in Postpartum Women with History of Gestational Diabetes
title_full Weight Change and Cardiometabolic Outcomes in Postpartum Women with History of Gestational Diabetes
title_fullStr Weight Change and Cardiometabolic Outcomes in Postpartum Women with History of Gestational Diabetes
title_full_unstemmed Weight Change and Cardiometabolic Outcomes in Postpartum Women with History of Gestational Diabetes
title_sort weight change and cardiometabolic outcomes in postpartum women with history of gestational diabetes
publisher MDPI AG
series Nutrients
issn 2072-6643
publishDate 2019-04-01
description Weight gain after childbirth is a significant risk factor for type 2 diabetes (T2DM) development after gestational diabetes mellitus (GDM). The level of weight loss achieved in diabetes prevention programs for women after GDM is often low but its effects on the cardiometabolic risk are not known. In a secondary analysis of a diabetes prevention program in postpartum women with history of gestational diabetes, we evaluated the effect of weight change on the cardiometabolic outcomes at 1-year follow-up. Of the 284 women randomized to the intervention arm, 206 with the final outcome measurements were included in the analyses. Participants were categorized into weight loss (&gt;2 kg, <i>n</i> = 74), weight stable (&#177;2 kg, <i>n</i> = 74) or weight gain (&gt;2 kg, <i>n</i> = 58) groups. The weight loss group had significantly greater decrease in glycated hemoglobin (HbA1c) than the weight gain group (&#8722;0.1 + 0.4% vs. 0 + 0.4%, <i>p</i> = 0.049). The weight loss group had significantly greater decrease in total cholesterol and low-density lipoprotein cholesterol cholesterol than the other two groups (<i>p</i> &lt; 0.05). The weight gain group had significantly greater increase in triglyceride and triglyceride:high-density lipoprotein cholesterol ratio compare with the other groups (<i>p</i> &lt; 0.01). Overall, a small amount of weight loss and prevention of further weight gain was beneficial to the cardiometabolic outcomes of postpartum women after GDM.
topic gestational diabetes
diabetes prevention program
weight loss
weight gain
postpartum
url https://www.mdpi.com/2072-6643/11/4/922
work_keys_str_mv AT siewlim weightchangeandcardiometabolicoutcomesinpostpartumwomenwithhistoryofgestationaldiabetes
AT vincentlversace weightchangeandcardiometabolicoutcomesinpostpartumwomenwithhistoryofgestationaldiabetes
AT sharleenoreilly weightchangeandcardiometabolicoutcomesinpostpartumwomenwithhistoryofgestationaldiabetes
AT edwardjanus weightchangeandcardiometabolicoutcomesinpostpartumwomenwithhistoryofgestationaldiabetes
AT jamesdunbar weightchangeandcardiometabolicoutcomesinpostpartumwomenwithhistoryofgestationaldiabetes
_version_ 1725328123515371520