Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet

Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet

The gut-liver axis is increasingly recognized as being involved in the pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD). Prolyl endopeptidase (PREP) plays a role in gut metabolic homeostasis and neurodegenerative diseases. We investigated the role of PREP disruption in the c...

Full description

Bibliographic Details
Main Authors:	Daixi Jiang, Jianbin Zhang, Shuangzhe Lin, Yuqin Wang, Yuanwen Chen, Jiangao Fan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	liver gut microbiota non-alcoholic fatty liver disease (NAFLD) gene knockout prolyl endopeptidase
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.628143/full

Similar Items

Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase
by: Bruno Becker, et al.
Published: (2018-08-01)

Isolation, purification and kinetic characterization of prolyl endopeptidase from Titicum aestivum
by: Abrahams, Adriam Mark
Published: (2013)

Tryptophan-Containing Dual Neuroprotective Peptides: Prolyl Endopeptidase Inhibition and Caenorhabditis elegans Protection from β-Amyloid Peptide Toxicity
by: Paloma Manzanares, et al.
Published: (2018-05-01)

Development of a Prolyl Endopeptidase Expression System In <i>Lactobacillus reuteri</i> to Reduce the Clinical Manifestation of Celiac Disease
by: Jew, Kara Lynn
Published: (2019)

A propeptide toolbox for secretion optimization of Flavobacterium meningosepticum endopeptidase in Lactococcus lactis
by: Pei Yu Lim, et al.
Published: (2017-12-01)

Prolyl Hydroxylase Domain-Containing Protein 3 Gene Expression in Chondrocytes Is Not Essential for Bone Development in Mice
by: Weirong Xing, et al.
Published: (2021-08-01)

Gut Microbiota Dysbiosis in Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study in Taiwan
by: Ming-Chao Tsai, et al.
Published: (2020-03-01)

Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure
by: Hocher B, et al.
Published: (2011-06-01)

Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis
by: Banrida Wahlang, et al.
Published: (2021-01-01)

Activity Gel Analysis of Endopeptidases in Rose Petals
by: Xiting Zhao, et al.
Published: (2016-03-01)

The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, including Atherosclerosis
by: Yannick eWaumans, et al.
Published: (2015-08-01)

Bariatric Surgery and Liver Disease: General Considerations and Role of the Gut–Liver Axis
by: Maria Cerreto, et al.
Published: (2021-07-01)

Étude structure/fonction de l'endopeptidase YPS1 de la levure S. cerevisiae
by: Dubé, Alexandre
Published: (2011)

The Therapeutic Implications of the Gut Microbiome and Probiotics in Patients with NAFLD
by: Brandon J. Perumpail, et al.
Published: (2019-02-01)

The Potential Protective Role of RUNX1 in Nonalcoholic Fatty Liver Disease
by: Laia Bertran, et al.
Published: (2021-05-01)

Non-alcoholic fatty liver and the gut microbiota
by: Stavros Bashiardes, et al.
Published: (2016-09-01)

Dysbiosis of gut microbiota after cholecystectomy is associated with non‐alcoholic fatty liver disease in mice
by: Qihan Wang, et al.
Published: (2021-08-01)

The Role of Gut Microbiota in Duodenal-Jejunal Bypass Surgery-Induced Improvement of Hepatic Steatosis in HFD-Fed Rats
by: Yi Gao, et al.
Published: (2021-04-01)

Molecular and Cellular Mediators of the Gut-Liver Axis in the Progression of Liver Diseases
by: Alix Bruneau, et al.
Published: (2021-09-01)

Reducing Immunoreactivity of Gliadins and Coeliac-Toxic Peptides Using Peptidases from <i>L. acidophilus</i> 5e2 and <i>A. niger</i>
by: Bartosz Brzozowski, et al.
Published: (2020-08-01)

Caractérisation de mutants de saccharomyces cerevisiae qui augmentent le « shedding » de l'endopeptidase Yps1 à la surface cellulaire
by: Coulombe, Célia
Published: (2013)

Gut Dysfunction and Non-alcoholic Fatty Liver Disease
by: Felix Grabherr, et al.
Published: (2019-09-01)

Serina endopeptidases de insetos e a interação inseto-planta
by: Lopes, Adriana Rios
Published: (2004)

Serina endopeptidases de insetos e a interação inseto-planta
by: Adriana Rios Lopes
Published: (2004)

Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis
by: Sergio Quesada-Vázquez, et al.
Published: (2020-01-01)

N-Acetyl-Seryl-Aspartyl-Lysyl-Proline Mitigates Experimental Colitis Through Inhibition of Intestinal Mucosal Inflammatory Responses via MEK-ERK Signaling
by: Yingying Shi, et al.
Published: (2020-05-01)

The Role of the Gut Microbiome in Liver Cirrhosis Treatment
by: Na Young Lee, et al.
Published: (2021-12-01)

Liver Cirrhosis and Sarcopenia from the Viewpoint of Dysbiosis
by: Hiroki Nishikawa, et al.
Published: (2020-07-01)

Dendrobii Officinalis, a traditional Chinese edible and officinal plant, accelerates liver recovery by regulating the gut-liver axis in NAFLD mice
by: Shan-Shan Lei, et al.
Published: (2019-10-01)

Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver InjurySummary
by: Kai Markus Schneider, et al.
Published: (2021-01-01)

The Role of the Gut Microbiome and its Derived Mediators in Nonalcoholic Fatty Liver Disease
by: Cosmas Rinaldi A. Lesmana, et al.
Published: (2019-12-01)

Prolyl hydroxylases:cloning and characterization of novel human and plant prolyl 4-hydroxylases, and three human prolyl 3-hydroxylases
by: Fonsén, P. (Päivi)
Published: (2007)

Sex-Dependent Effects on Liver Inflammation and Gut Microbial Dysbiosis After Continuous Developmental Exposure to Trichloroethylene in Autoimmune-Prone Mice
by: Sarah J. Blossom, et al.
Published: (2020-10-01)

Patophysiology of nonalcoholic fatty liver disease
by: Ewa Krzewicka-Romaniuk, et al.
Published: (2019-09-01)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
by: Matthew E Cockman, et al.
Published: (2019-09-01)

A comprehensive review of the pharmacodynamics, pharmacokinetics and clinical effects of the neutral endopeptidase inhibitor racecadotril
by: Marion eEberlin, et al.
Published: (2012-05-01)

Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis
by: Liangzhong Zhao, et al.
Published: (2020-03-01)

Translational Approaches with Antioxidant Phytochemicals against Alcohol-Mediated Oxidative Stress, Gut Dysbiosis, Intestinal Barrier Dysfunction and Fatty Liver Disease
by: Jacob W. Ballway, et al.
Published: (2021-03-01)

Prebiotic Impacts of Soybean Residue (Okara) on Eubiosis/Dysbiosis Condition of the Gut and the Possible Effects on Liver and Kidney Functions
by: Mohammed Sharif Swallah, et al.
Published: (2021-01-01)

Microbial Intervention as a Novel Target in Treatment of Non-Alcoholic Fatty Liver Disease Progression
by: Youlian Zhou, et al.
Published: (2018-12-01)

Cannot write session to /tmp/vufind_sessions/sess_83pukq6r0504on6hraj0qi4llj