Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research

Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research

Faced with the need to find new drugs for all kinds of diseases, science sees that Nature offers numerous classes of compounds showing an impressively high biological potential. Among those are the cyclodepsipeptides, hybrid structures composed of amino and hydroxy acids. In the past decades numerou...

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Main Authors: Sivatharushan Sivanathan, Jürgen Scherkenbeck
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Molecules
Subjects:
natural product
cyclodepsipeptide
solid-phase synthesis
biological activity
total synthesis
Online Access:http://www.mdpi.com/1420-3049/19/8/12368
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spelling doaj-ee9e7252a2b242df87f8043c60ef048c2020-11-24T22:23:55ZengMDPI AGMolecules1420-30492014-08-01198123681242010.3390/molecules190812368molecules190812368Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug ResearchSivatharushan Sivanathan0Jürgen Scherkenbeck1Bergische Universität Wuppertal, Fachgruppe C, Organic Chemistry, Gaußstraße 20, Wuppertal 42119, GermanyBergische Universität Wuppertal, Fachgruppe C, Organic Chemistry, Gaußstraße 20, Wuppertal 42119, GermanyFaced with the need to find new drugs for all kinds of diseases, science sees that Nature offers numerous classes of compounds showing an impressively high biological potential. Among those are the cyclodepsipeptides, hybrid structures composed of amino and hydroxy acids. In the past decades numerous cyclodepsipeptides have been isolated and their potential as drugs has been studied extensively. For several cyclodepsipeptides total syntheses both in solution and on solid-phase have been established, allowing the production of combinatorial libraries. In addition, the biosynthesis of specific cyclodepsipeptides has been elucidated and used for the chemoenzymatic preparation of nonnatural analogues. This review summarizes the recent literature on cyclic tetra- to decadepsipeptides, composed exclusively of α-amino- and α-hydroxy acids.http://www.mdpi.com/1420-3049/19/8/12368natural productcyclodepsipeptidesolid-phase synthesisbiological activitytotal synthesis
collection DOAJ
language English
format Article
sources DOAJ
author Sivatharushan Sivanathan
Jürgen Scherkenbeck
spellingShingle Sivatharushan Sivanathan
Jürgen Scherkenbeck
Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research
Molecules
natural product
cyclodepsipeptide
solid-phase synthesis
biological activity
total synthesis
author_facet Sivatharushan Sivanathan
Jürgen Scherkenbeck
author_sort Sivatharushan Sivanathan
title Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research
title_short Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research
title_full Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research
title_fullStr Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research
title_full_unstemmed Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research
title_sort cyclodepsipeptides: a rich source of biologically active compounds for drug research
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2014-08-01
description Faced with the need to find new drugs for all kinds of diseases, science sees that Nature offers numerous classes of compounds showing an impressively high biological potential. Among those are the cyclodepsipeptides, hybrid structures composed of amino and hydroxy acids. In the past decades numerous cyclodepsipeptides have been isolated and their potential as drugs has been studied extensively. For several cyclodepsipeptides total syntheses both in solution and on solid-phase have been established, allowing the production of combinatorial libraries. In addition, the biosynthesis of specific cyclodepsipeptides has been elucidated and used for the chemoenzymatic preparation of nonnatural analogues. This review summarizes the recent literature on cyclic tetra- to decadepsipeptides, composed exclusively of α-amino- and α-hydroxy acids.
topic natural product
cyclodepsipeptide
solid-phase synthesis
biological activity
total synthesis
url http://www.mdpi.com/1420-3049/19/8/12368
work_keys_str_mv AT sivatharushansivanathan cyclodepsipeptidesarichsourceofbiologicallyactivecompoundsfordrugresearch
AT jurgenscherkenbeck cyclodepsipeptidesarichsourceofbiologicallyactivecompoundsfordrugresearch
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