Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation.

Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation.

Hepatitis C virus (HCV) infection constitutes a significant health burden worldwide, because it is a major etiologic agent of chronic liver disease, cirrhosis and hepatocellular carcinoma. HCV replication cycle is closely tied to lipid metabolism and infection by this virus causes profound changes i...

Full description

Bibliographic Details
Main Authors:	Lidia Mingorance, Victoria Castro, Ginés Ávila-Pérez, Gema Calvo, María Josefa Rodriguez, José L Carrascosa, Sofía Pérez-Del-Pulgar, Xavier Forns, Pablo Gastaminza
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-09-01
Series:	PLoS Pathogens
Online Access:	https://doi.org/10.1371/journal.ppat.1007284

Similar Items

Differential Roles of Lipin1 and Lipin2 in the Hepatitis C Virus Replication Cycle
by: Victoria Castro, et al.
Published: (2020-06-01)

Differential Roles of Lipin1 and Lipin2 in the Hepatitis C Virus Replication Cycle
by: Victoria Castro, et al.
Published: (2019-11-01)

Crystal structure of a lipin/Pah phosphatidic acid phosphatase
by: Valerie I. Khayyo, et al.
Published: (2020-03-01)

Publisher Correction: Crystal structure of a lipin/Pah phosphatidic acid phosphatase
by: Valerie I. Khayyo, et al.
Published: (2020-04-01)

Mammalian lipin phosphatidic acid phosphatases in lipid synthesis and beyond: metabolic and inflammatory disorders
by: Karen Reue, et al.
Published: (2019-04-01)

The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDLs⃞
by: Maroun Bou Khalil, et al.
Published: (2009-01-01)

Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism*
by: Karen Reue, et al.
Published: (2008-12-01)

NLIP and HAD-like Domains of Pah1 and Lipin 1 Phosphatidate Phosphatases Are Essential for Their Catalytic Activities
by: Wei-Hsin Hsu, et al.
Published: (2021-09-01)

Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity
by: Andrew J. Lutkewitte, et al.
Published: (2020-09-01)

Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice
by: George G. Schweitzer, et al.
Published: (2015-04-01)

A review of phosphatidate phosphatase assays
by: Prabuddha Dey, et al.
Published: (2020-12-01)

Persistent Transcriptional Alterations after Hepatitis C Virus Elimination in Cell Culture
by: Victoria Castro, et al.
Published: (2020-06-01)

Host Pah1p phosphatidate phosphatase limits viral replication by regulating phospholipid synthesis.
by: Zhenlu Zhang, et al.
Published: (2018-04-01)

The membrane bound phosphatidic add phosphatase from avocado
by: Pearce, Matthew L.
Published: (1997)

Characterization of a soluble phosphatidic acid phosphatase in bitter melon (Momordica charantia).
by: Heping Cao, et al.
Published: (2014-01-01)

Glycerolipid synthesis in rat adipose tissue. II. Properties and distribution of phosphatidate phosphatase
by: S.C. Jamdar, et al.
Published: (1973-09-01)

THE ROLE OF TOMBUSVIRUS REPLICASE PROTEINS AND RNA IN REPLICASE ASSEMBLY, REPLICATION AND RECOMBINATION
by: Panaviene, Zivile Sliesaraviciute
Published: (2004)

Brain lipins of normal rats
by: Cribbett, James Romayne
Published: (2014)

Lipin proteins and metabolic homeostasis
by: Karen Reue, et al.
Published: (2009-01-01)

Selection for replicases in protocells.
by: Ginestra Bianconi, et al.
Published: (2013-01-01)

TORC1 regulates Pah1 phosphatidate phosphatase activity via the Nem1/Spo7 protein phosphatase complex.
by: Emmanuelle Dubots, et al.
Published: (2014-01-01)

Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling
by: Philip V'kovski, et al.
Published: (2019-01-01)

Suppression of DS1 phosphatidic acid phosphatase confirms resistance to Ralstonia solanacearum in Nicotiana benthamiana.
by: Masahito Nakano, et al.
Published: (2013-01-01)

Fat-regulating phosphatidic acid phosphatase: a review of its roles and regulation in lipid homeostasis
by: George M. Carman, et al.
Published: (2019-01-01)

Yeast phosphatidic acid phosphatase Pah1 hops and scoots along the membrane phospholipid bilayer
by: Joanna M. Kwiatek, et al.
Published: (2020-08-01)

Fluorescence spectroscopy measures yeast PAH1-encoded phosphatidate phosphatase interaction with liposome membranes
by: Zhi Xu, et al.
Published: (2012-03-01)

Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
by: Sheena Dass, et al.
Published: (2021-05-01)

Temporal and spatial regulation of lipin 1 and 2
by: Grimsey, Neil Justin
Published: (2009)

Lipin-1 expression is critical for keratinocyte differentiation[S]
by: Minjung Chae, et al.
Published: (2016-04-01)

Exploring the role of lipin1 in mitophagy process using lipin1 deficient-EGFP tagged LC3 transgenic mice
by: Alshudukhi, Abdullah Ali
Published: (2017)

The Effect of Hydroalcoholic Extract of Allium Latifolium on the Liver Phosphatidate Phosphatase and Serum Lipid Profile in Hyperlipidemic Rats
by: E Heidarian, et al.
Published: (2013-07-01)

Phospholipase D/phosphatidic acid phosphatase signal transduction pathway in post-infarction congestive heart failure
by: Yu, Changhua
Published: (2007)

Divergent changes in cardiac phospholipase D-phosphatidic acid phosphatase activities during insulin-dependent diabetes
by: Williams, Sean Angela
Published: (2013)

Phospholipase D/phosphatidic acid phosphatase signal transduction pathway in post-infarction congestive heart failure
by: Yu, Changhua
Published: (2007)

Divergent changes in cardiac phospholipase D-phosphatidic acid phosphatase activities during insulin-dependent diabetes
by: Williams, Sean Angela
Published: (2013)

Phospholipase D/phosphatidic acid phosphatase signal transduction pathway in post-infarction congestive heart failure
by: Yu, Changhua
Published: (2007)

An evolutionarily conserved phosphatidate phosphatase maintains lipid droplet number and endoplasmic reticulum morphology but not nuclear morphology
by: Anoop Narayana Pillai, et al.
Published: (2017-11-01)

Characterisation of a plastid DNA replicase
by: Seow, Sze Inn Fiona
Published: (2004)

Phosphatides of Atypical Mycobacteria
by: Hollingsworth, Russell C.
Published: (1968)

Molecular Characterization of a Tolerant Saline-Alkali Chlorella Phosphatidate Phosphatase That Confers NaCl and Sorbitol Tolerance
by: Jingang Wang, et al.
Published: (2021-09-01)

Cannot write session to /tmp/vufind_sessions/sess_a92lhoimcm1tqlf12ssfbqdiqg