Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture

Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture

Low-density lipoprotein receptor (LDLR) mediates hepatic clearance of plasma cholesterol; proprotein convertase subtilisin/kexin 9 (PCSK9) opposes this clearance by promoting LDLR degradation. The plant flavonoid quercetin-3-β-d-glucoside (Q3G) has been shown to reduce hypercholesterolemia in experi...

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Bibliographic Details
Main Authors: Majambu Mbikay, Francine Sirois, Sonia Simoes, Janice Mayne, Michel Chrétien
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Quercetin
Proprotein convertase
Low-density lipoprotein receptor
Cholesterol
Sortilin
Hepatocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000771

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http://www.sciencedirect.com/science/article/pii/S2211546314000771

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