Normothermic ex vivo Heart Perfusion Combined With Melatonin Enhances Myocardial Protection in Rat Donation After Circulatory Death Hearts via Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis

Normothermic ex vivo Heart Perfusion Combined With Melatonin Enhances Myocardial Protection in Rat Donation After Circulatory Death Hearts via Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis

ObjectiveThe adoption of hearts from donation after circulatory death (DCD) is a promising approach for the shortage of suitable organs in heart transplantation. However, DCD hearts suffer from serious ischemia/reperfusion injury (IRI). Recent studies demonstrate that nucleotide-binding oligomerizat...

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Bibliographic Details
Main Authors: Jun Lu, Liwei Xu, Zifeng Zeng, Chuqing Xue, Jiale Li, Xiong Chen, Pengyu Zhou, Shaoyan Lin, Yuhui Liao, Xianjin Du, Ronghua Yang, Shaoyi Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
donation after circulatory death
normothermic ex vivo heart perfusion
melatonin
heart preservation
ischemia/reperfusion injury
pyroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.733183/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.733183/full

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