Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia
Resistance to tyrosine kinase inhibitors (TKI) is a limitation to their use in treating chronic myelogenous leukemia (CML). Here, the authors show that targeting the ubiquitin peptidase USP47 overcomes TKI resistance and eliminates leukaemia stem/progenitor cells in primary and xenograft CML murine...
Full description
Bibliographic Details
| Main Authors: |
Hu Lei,
Han-Zhang Xu,
Hui-Zhuang Shan,
Meng Liu,
Ying Lu,
Zhi-Xiao Fang,
Jin Jin,
Bo Jing,
Xin-Hua Xiao,
Shen-Meng Gao,
Feng-Hou Gao,
Li Xia,
Li Yang,
Li-Gen Liu,
Wei-Wei Wang,
Chuan-Xu Liu,
Yin Tong,
Yun-Zhao Wu,
Jun-Ke Zheng,
Guo-Qiang Chen,
Li Zhou,
Ying-Li Wu |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2021-01-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-020-20259-0
|
|---|
