Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants
<p>Abstract</p> <p>Background</p> <p>Fibromyalgia (FM) is characterized by chronic widespread pain, which is often refractory to conventional painkillers. Numerous clinical studies have demonstrated that antidepressants are effective in treating FM pain. We previously e...
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doaj-ef91fd75df624d28a7fde17d465415b02020-11-25T03:16:58ZengSAGE PublishingMolecular Pain1744-80692011-09-01716910.1186/1744-8069-7-69Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressantsMukae TakehiroAraki KoheiNagai JunUchida HitoshiNishiyori MichikoKishioka ShirohUeda Hiroshi<p>Abstract</p> <p>Background</p> <p>Fibromyalgia (FM) is characterized by chronic widespread pain, which is often refractory to conventional painkillers. Numerous clinical studies have demonstrated that antidepressants are effective in treating FM pain. We previously established a mouse model of FM-like pain, induced by intermittent cold stress (ICS).</p> <p>Results</p> <p>In this study, we find that ICS exposure causes a transient increase in plasma corticosterone concentration, but not in anxiety or depression-like behaviors. A single intrathecal injection of an antidepressant, such as milnacipran, amitriptyline, mianserin or paroxetine, had an acute analgesic effect on ICS-induced thermal hyperalgesia at post-stress day 1 in a dose-dependent manner. In addition, repeated daily antidepressant treatments during post-stress days 1-5 gradually reversed the reduction in thermal pain threshold, and this recovery was maintained for at least 7 days after the final treatment. In addition, relief from mechanical allodynia, induced by ICS exposure, was also observed at day 9 after the cessation of antidepressant treatment. In contrast, the intravenous administration of these antidepressants at conventional doses failed to provide relief.</p> <p>Conclusions</p> <p>These results suggest that the repetitive intrathecal administration of antidepressants permanently cures ICS-induced FM pain in mice.</p> http://www.molecularpain.com/content/7/1/69fibromyalgiacold stressvicious circleantidepressantallodyniahyperalgesia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mukae Takehiro Araki Kohei Nagai Jun Uchida Hitoshi Nishiyori Michiko Kishioka Shiroh Ueda Hiroshi |
spellingShingle |
Mukae Takehiro Araki Kohei Nagai Jun Uchida Hitoshi Nishiyori Michiko Kishioka Shiroh Ueda Hiroshi Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants Molecular Pain fibromyalgia cold stress vicious circle antidepressant allodynia hyperalgesia |
author_facet |
Mukae Takehiro Araki Kohei Nagai Jun Uchida Hitoshi Nishiyori Michiko Kishioka Shiroh Ueda Hiroshi |
author_sort |
Mukae Takehiro |
title |
Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants |
title_short |
Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants |
title_full |
Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants |
title_fullStr |
Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants |
title_full_unstemmed |
Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants |
title_sort |
permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants |
publisher |
SAGE Publishing |
series |
Molecular Pain |
issn |
1744-8069 |
publishDate |
2011-09-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Fibromyalgia (FM) is characterized by chronic widespread pain, which is often refractory to conventional painkillers. Numerous clinical studies have demonstrated that antidepressants are effective in treating FM pain. We previously established a mouse model of FM-like pain, induced by intermittent cold stress (ICS).</p> <p>Results</p> <p>In this study, we find that ICS exposure causes a transient increase in plasma corticosterone concentration, but not in anxiety or depression-like behaviors. A single intrathecal injection of an antidepressant, such as milnacipran, amitriptyline, mianserin or paroxetine, had an acute analgesic effect on ICS-induced thermal hyperalgesia at post-stress day 1 in a dose-dependent manner. In addition, repeated daily antidepressant treatments during post-stress days 1-5 gradually reversed the reduction in thermal pain threshold, and this recovery was maintained for at least 7 days after the final treatment. In addition, relief from mechanical allodynia, induced by ICS exposure, was also observed at day 9 after the cessation of antidepressant treatment. In contrast, the intravenous administration of these antidepressants at conventional doses failed to provide relief.</p> <p>Conclusions</p> <p>These results suggest that the repetitive intrathecal administration of antidepressants permanently cures ICS-induced FM pain in mice.</p> |
topic |
fibromyalgia cold stress vicious circle antidepressant allodynia hyperalgesia |
url |
http://www.molecularpain.com/content/7/1/69 |
work_keys_str_mv |
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