Transcriptome profiling of peripheral blood cells identifies potential biomarkers for doxorubicin cardiotoxicity in a rat model.

Doxorubicin (DOX), a widely used anticancer agent, can cause an unpredictable cardiac toxicity which remains a major limitation in cancer chemotherapy. There is a need for noninvasive, sensitive and specific biomarkers which will allow identifying patients at risk for DOX-induced cardiotoxicity to p...

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Bibliographic Details
Main Authors: Valentina K Todorova, Marjorie L Beggs, Robert R Delongchamp, Ishwori Dhakal, Issam Makhoul, Jeanne Y Wei, V Suzanne Klimberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3507887?pdf=render