Repositioning drugs by targeting network modules: a Parkinson’s disease case study

Abstract Background Much effort has been devoted to the discovery of specific mechanisms between drugs and single targets to date. However, as biological systems maintain homeostasis at the level of functional networks robustly controlling the internal environment, such networks commonly contain mul...

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Bibliographic Details
Main Authors: Zongliang Yue, Itika Arora, Eric Y. Zhang, Vincent Laufer, S. Louis Bridges, Jake Y. Chen
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Bioinformatics
Online Access:http://link.springer.com/article/10.1186/s12859-017-1889-0