Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis

The use of probiotics in reproductive-related dysbiosis is an area of continuous progress due to the growing interest from clinicians and patients suffering from recurrent reproductive microbiota disorders. An imbalance in the natural colonization sites related to reproductive health—vaginal, cervic...

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Main Authors: Ana López-Moreno, Margarita Aguilera
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Clinical Medicine
Subjects:
VVC
IVF
Online Access:https://www.mdpi.com/2077-0383/10/7/1461
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spelling doaj-f0bae489712a4f7b9b226126d7e845cd2021-04-02T23:00:57ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01101461146110.3390/jcm10071461Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-AnalysisAna López-Moreno0Margarita Aguilera1Department of Microbiology, Faculty of Pharmacy, Campus of Cartuja, University of Granada, 18071 Granada, SpainDepartment of Microbiology, Faculty of Pharmacy, Campus of Cartuja, University of Granada, 18071 Granada, SpainThe use of probiotics in reproductive-related dysbiosis is an area of continuous progress due to the growing interest from clinicians and patients suffering from recurrent reproductive microbiota disorders. An imbalance in the natural colonization sites related to reproductive health—vaginal, cervicovaginal, endometrial, and pregnancy-related altered microbiota—could play a decisive role in reproductive outcomes. Oral and vaginal administrations are in continuous discussion regarding the clinical effects pursued, but the oral route is used and studied more often despite the need for further transference to the colonization site. The aim of the present review was to retrieve the standardized protocols of vaginal probiotics commonly used for investigating their microbiota modulation capacities. Most of the studies selected focused on treating bacterial vaginosis (BV) as the most common dysbiosis; a few studies focused on vulvovaginal candidiasis (VVC) and on pretreatment during in vitro fertilization (IVF). Vaginal probiotic doses administered were similar to oral probiotics protocols, ranging from ≥10<sup>7</sup> CFU/day to 2.5 × 10<sup>10</sup> CFU/day, but were highly variable regarding the treatment duration timing. Moderate vaginal microbiota modulation was achieved; the relative abundance of abnormal microbiota decreased and <i>Lactobacillus</i> species increased.https://www.mdpi.com/2077-0383/10/7/1461vaginal probioticsreproductive dysbiosisbacterial vaginosisVVCIVF
collection DOAJ
language English
format Article
sources DOAJ
author Ana López-Moreno
Margarita Aguilera
spellingShingle Ana López-Moreno
Margarita Aguilera
Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis
Journal of Clinical Medicine
vaginal probiotics
reproductive dysbiosis
bacterial vaginosis
VVC
IVF
author_facet Ana López-Moreno
Margarita Aguilera
author_sort Ana López-Moreno
title Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis
title_short Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis
title_full Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis
title_fullStr Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis
title_full_unstemmed Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis
title_sort vaginal probiotics for reproductive health and related dysbiosis: systematic review and meta-analysis
publisher MDPI AG
series Journal of Clinical Medicine
issn 2077-0383
publishDate 2021-04-01
description The use of probiotics in reproductive-related dysbiosis is an area of continuous progress due to the growing interest from clinicians and patients suffering from recurrent reproductive microbiota disorders. An imbalance in the natural colonization sites related to reproductive health—vaginal, cervicovaginal, endometrial, and pregnancy-related altered microbiota—could play a decisive role in reproductive outcomes. Oral and vaginal administrations are in continuous discussion regarding the clinical effects pursued, but the oral route is used and studied more often despite the need for further transference to the colonization site. The aim of the present review was to retrieve the standardized protocols of vaginal probiotics commonly used for investigating their microbiota modulation capacities. Most of the studies selected focused on treating bacterial vaginosis (BV) as the most common dysbiosis; a few studies focused on vulvovaginal candidiasis (VVC) and on pretreatment during in vitro fertilization (IVF). Vaginal probiotic doses administered were similar to oral probiotics protocols, ranging from ≥10<sup>7</sup> CFU/day to 2.5 × 10<sup>10</sup> CFU/day, but were highly variable regarding the treatment duration timing. Moderate vaginal microbiota modulation was achieved; the relative abundance of abnormal microbiota decreased and <i>Lactobacillus</i> species increased.
topic vaginal probiotics
reproductive dysbiosis
bacterial vaginosis
VVC
IVF
url https://www.mdpi.com/2077-0383/10/7/1461
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