Dysfunctional Crohn's disease-associated NOD2 polymorphisms cannot be reliably predicted on the basis of RIPK2-binding or membrane association

Dysfunctional Crohn's disease-associated NOD2 polymorphisms cannot be reliably predicted on the basis of RIPK2-binding or membrane association

Polymorphisms in NOD2 represent the single greatest genetic risk factor for the development of Crohn's disease. Three different non-synonomous NOD2 polymorphisms - R702W, G908R, L1007fsincC - account for roughly 80 % of all NOD2-associated cases of Crohn's disease and are reported to resul...

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Bibliographic Details
Main Authors: Rhiannon eParkhouse, Tom Peter Monie
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Immunology
Subjects:
Inflammation
Inflammatory Bowel Diseases
Nod2 Signaling Adaptor Protein
NFkB
Single nucleotide polymorphisms (SNPs)
RIP2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00521/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00521/full

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