Ultrasonic Characteristics of Cardiovascular Changes in Children with Hutchinson–Gilford Progeria Syndrome: A Comparative Study with Normal Children and Aging People
Background. The cardiovascular characteristics of children with Hutchinson-Gilford progeria syndrome (HGPS) remain unclear. The present study is aimed at evaluating the cardiovascular changes with ultrasound examination in children with HGPS and compared these with those in normal children and older...
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doaj-f1056ec66909400f964656e70b2c91902020-11-25T03:26:00ZengHindawi LimitedBioMed Research International2314-61332314-61412020-01-01202010.1155/2020/96318519631851Ultrasonic Characteristics of Cardiovascular Changes in Children with Hutchinson–Gilford Progeria Syndrome: A Comparative Study with Normal Children and Aging PeopleXiao-Ni Zhao0Hong-Ping Song1Fan Yang2Dang-Jie Wu3Wen-Qing Gong4Ying Zhang5Xin Sun6Min-Juan Zheng7Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032 Shaanxi Province, ChinaDepartment of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032 Shaanxi Province, ChinaDepartment of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032 Shaanxi Province, ChinaDepartment of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032 Shaanxi Province, ChinaDepartment of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032 Shaanxi Province, ChinaDepartment of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032 Shaanxi Province, ChinaDepartment of Pediatrics, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032 Shaanxi Province, ChinaDepartment of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032 Shaanxi Province, ChinaBackground. The cardiovascular characteristics of children with Hutchinson-Gilford progeria syndrome (HGPS) remain unclear. The present study is aimed at evaluating the cardiovascular changes with ultrasound examination in children with HGPS and compared these with those in normal children and older people. Methods. Seven HGPS children, 21 age-matched healthy children, and 14 older healthy volunteers were evaluated by three-dimensional echocardiography (including strain analysis) and carotid elasticity examination with the echo-tracking technique. Results. Children with HGPS had higher left ventricular ejection fraction (LVEF) and global longitudinal strain, when compared to older healthy volunteers (P<0.05). However, these parameters were not significantly different, when compared to those in healthy children. Furthermore, children with HGPS had lower average peak times in the left ventricle, when compared with the other two groups. For the structure of the carotid artery detected by ultrasound, the abnormality rates were similar between children with HGPS and older healthy volunteers (83.3% vs. 71.4%). The elastic parameters, elastic modulus, stiffness parameter, and pulsed wave transmittal velocity of children with HGPS were lower, when compared to those in older healthy volunteers (P<0.05), while they were higher with arterial compliance (P>0.05). Furthermore, no significant difference existed among the vascular elastic parameters between HGPS and normal children. Conclusion. HGPS children had impaired left ventricular (LV) synchrony, when compared to normal children, although the difference in LVEF was not statistically significant. Furthermore, the structural abnormality of the carotid artery in HGPS children was similar to that in older people, although the index of elasticity appears to be more favorable. These results suggest that the cardiovascular system in HGPS children differs from natural aging.http://dx.doi.org/10.1155/2020/9631851 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiao-Ni Zhao Hong-Ping Song Fan Yang Dang-Jie Wu Wen-Qing Gong Ying Zhang Xin Sun Min-Juan Zheng |
spellingShingle |
Xiao-Ni Zhao Hong-Ping Song Fan Yang Dang-Jie Wu Wen-Qing Gong Ying Zhang Xin Sun Min-Juan Zheng Ultrasonic Characteristics of Cardiovascular Changes in Children with Hutchinson–Gilford Progeria Syndrome: A Comparative Study with Normal Children and Aging People BioMed Research International |
author_facet |
Xiao-Ni Zhao Hong-Ping Song Fan Yang Dang-Jie Wu Wen-Qing Gong Ying Zhang Xin Sun Min-Juan Zheng |
author_sort |
Xiao-Ni Zhao |
title |
Ultrasonic Characteristics of Cardiovascular Changes in Children with Hutchinson–Gilford Progeria Syndrome: A Comparative Study with Normal Children and Aging People |
title_short |
Ultrasonic Characteristics of Cardiovascular Changes in Children with Hutchinson–Gilford Progeria Syndrome: A Comparative Study with Normal Children and Aging People |
title_full |
Ultrasonic Characteristics of Cardiovascular Changes in Children with Hutchinson–Gilford Progeria Syndrome: A Comparative Study with Normal Children and Aging People |
title_fullStr |
Ultrasonic Characteristics of Cardiovascular Changes in Children with Hutchinson–Gilford Progeria Syndrome: A Comparative Study with Normal Children and Aging People |
title_full_unstemmed |
Ultrasonic Characteristics of Cardiovascular Changes in Children with Hutchinson–Gilford Progeria Syndrome: A Comparative Study with Normal Children and Aging People |
title_sort |
ultrasonic characteristics of cardiovascular changes in children with hutchinson–gilford progeria syndrome: a comparative study with normal children and aging people |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2020-01-01 |
description |
Background. The cardiovascular characteristics of children with Hutchinson-Gilford progeria syndrome (HGPS) remain unclear. The present study is aimed at evaluating the cardiovascular changes with ultrasound examination in children with HGPS and compared these with those in normal children and older people. Methods. Seven HGPS children, 21 age-matched healthy children, and 14 older healthy volunteers were evaluated by three-dimensional echocardiography (including strain analysis) and carotid elasticity examination with the echo-tracking technique. Results. Children with HGPS had higher left ventricular ejection fraction (LVEF) and global longitudinal strain, when compared to older healthy volunteers (P<0.05). However, these parameters were not significantly different, when compared to those in healthy children. Furthermore, children with HGPS had lower average peak times in the left ventricle, when compared with the other two groups. For the structure of the carotid artery detected by ultrasound, the abnormality rates were similar between children with HGPS and older healthy volunteers (83.3% vs. 71.4%). The elastic parameters, elastic modulus, stiffness parameter, and pulsed wave transmittal velocity of children with HGPS were lower, when compared to those in older healthy volunteers (P<0.05), while they were higher with arterial compliance (P>0.05). Furthermore, no significant difference existed among the vascular elastic parameters between HGPS and normal children. Conclusion. HGPS children had impaired left ventricular (LV) synchrony, when compared to normal children, although the difference in LVEF was not statistically significant. Furthermore, the structural abnormality of the carotid artery in HGPS children was similar to that in older people, although the index of elasticity appears to be more favorable. These results suggest that the cardiovascular system in HGPS children differs from natural aging. |
url |
http://dx.doi.org/10.1155/2020/9631851 |
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