The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection.

The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection.

CCL28 (MEC) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASC) in the mucosal lamina propria (MLP). Mucosal HIV-specific IgA are detected in HIV-infection and exposure. The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the ef...

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Bibliographic Details
Main Authors: Eleonora Castelletti, Sergio Lo Caputo, Louise Kuhn, Manuela Borelli, Johanna Gajardo, Moses Sinkala, Daria Trabattoni, Chipepo Kankasa, Eleonora Lauri, Alberto Clivio, Luca Piacentini, Dorothy H Bray, Grace M Aldrovandi, Donald M Thea, Francisco Veas, Manuela Nebuloni, Francesco Mazzotta, Mario Clerici
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1989139?pdf=render

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http://europepmc.org/articles/PMC1989139?pdf=render

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