Evaluation of [ 13 N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain

Evaluation of [ 13 N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain

Abstract Purpose The conversion of synaptic glutamate to glutamine in astrocytes by glutamine synthetase (GS) is critical to maintaining healthy brain activity and may be disrupted in several brain disorders. As the GS catalysed conversion of glutamate to glutamine requires ammonia, we evaluated whe...

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Bibliographic Details
Main Authors: Alice Egerton, Joel T. Dunn, Nisha Singh, Zilin Yu, Jim O’Doherty, Ivan Koychev, Jessica Webb, Simon Claridge, Federico E. Turkheimer, Paul K. Marsden, Alexander Hammers, Antony Gee
Format: Article
Language:English
Published: SpringerOpen 2020-12-01
Series:EJNMMI Research
Subjects:
Glutamate
Glutamate turnover
PET
Test–retest
Arterial input function
Metabolites
Online Access:https://doi.org/10.1186/s13550-020-00731-0

Internet

https://doi.org/10.1186/s13550-020-00731-0

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