Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion.

Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion.

Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is an unmet need for innovative tools to block transmission in endemic areas. In t...

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Bibliographic Details
Main Authors: Lara Maria Kalempa Demeu, Rodrigo Jahn Soares, Juliana Severo Miranda, Lisandro A Pacheco-Lugo, Kelin Gonçalves Oliveira, Cristian Andrés Cortez Plaza, Philippe Billiald, Juliana Ferreira de Moura, Nobuko Yoshida, Larissa Magalhães Alvarenga, Wanderson Duarte DaRocha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0223773

Internet

https://doi.org/10.1371/journal.pone.0223773

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