VEGF/VEGFR2 signaling regulates hippocampal axon branching during development

VEGF/VEGFR2 signaling regulates hippocampal axon branching during development

Axon branching is crucial for proper formation of neuronal networks. Although originally identified as an angiogenic factor, VEGF also signals directly to neurons to regulate their development and function. Here we show that VEGF and its receptor VEGFR2 (also known as KDR or FLK1) are expressed in m...

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Bibliographic Details
Main Authors: Robert Luck, Severino Urban, Andromachi Karakatsani, Eva Harde, Sivakumar Sambandan, LaShae Nicholson, Silke Haverkamp, Rebecca Mann, Ana Martin-Villalba, Erin Margaret Schuman, Amparo Acker-Palmer, Carmen Ruiz de Almodóvar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
develomental neuroscience
axon branching
neuro-vascular link
VEGF
VEGFR2
hippocampus
Online Access:https://elifesciences.org/articles/49818

Internet

https://elifesciences.org/articles/49818

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