Integrin Activation Enables Sensitive Detection of Functional CD4+ and CD8+ T Cells: Application to Characterize SARS-CoV-2 Immunity

Integrin Activation Enables Sensitive Detection of Functional CD4+ and CD8+ T Cells: Application to Characterize SARS-CoV-2 Immunity

We have previously shown that conformational change in the β2-integrin is a very early activation marker that can be detected with fluorescent multimers of its ligand intercellular adhesion molecule (ICAM)-1 for rapid assessment of antigen-specific CD8+ T cells. In this study, we describe a modified...

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Bibliographic Details
Main Authors: Anna Schöllhorn, Juliane Schuhmacher, Luciana Besedovsky, Rolf Fendel, Anja T. R. Jensen, Stefan Stevanović, Tanja Lange, Hans-Georg Rammensee, Jan Born, Cécile Gouttefangeas, Stoyan Dimitrov
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
integrin activation
antigen specificity
CD4+ T cells
CD8+ T cells
SARS-CoV-2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.626308/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.626308/full

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