Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages

Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages

Tumor-associated macrophages may either promote or suppress tumor growth depending on their activation status. Interferon-γ (IFN-γ) has been identified as a key factor for inducing tumoricidal M1 phenotype in macrophages. However, it remains unclear whether IFN-γ is sufficient or if additional stimu...

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Bibliographic Details
Main Authors: Elisabeth Müller, Panagiotis F. Christopoulos, Sanjib Halder, Anna Lunde, Kahsai Beraki, Martin Speth, Inger Øynebråten, Alexandre Corthay
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
macrophages
tumoricidal
toll-like receptors
interferon-γ
cancer
nitric oxide
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01383/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01383/full

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