Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage

Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage

Failure of facial prominence fusion causes cleft lip and palate (CL/P), a common human birth defect. Several potential mechanisms can be envisioned that would result in CL/P, including failure of prominence growth and/or alignment as well as a failure of fusion of the juxtaposed epithelial seams. He...

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Bibliographic Details
Main Authors: Rebecca M. Green, Weiguo Feng, Tzulip Phang, Jennifer L. Fish, Hong Li, Richard A. Spritz, Ralph S. Marcucio, Joan Hooper, Heather Jamniczky, Benedikt Hallgrímsson, Trevor Williams
Format: Article
Language:English
Published: The Company of Biologists 2015-01-01
Series:Disease Models & Mechanisms
Subjects:
Craniofacial
TFAP2A
AP-2α
BOFS
Branchio-oculofacial syndrome
Cleft lip/palate
Geometric morphometrics
Fgf signaling pathway
Online Access:http://dmm.biologists.org/content/8/1/31

Internet

http://dmm.biologists.org/content/8/1/31

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