Toward the Synthesis and Improved Biopotential of an N-methylated Analog of a Proline-Rich Cyclic Tetrapeptide from Marine Bacteria

Toward the Synthesis and Improved Biopotential of an N-methylated Analog of a Proline-Rich Cyclic Tetrapeptide from Marine Bacteria

An N-methylated analog of a marine bacteria-derived natural proline-rich tetracyclopeptide was synthesized by coupling the deprotected dipeptide fragments Boc-l-prolyl-l-N-methylleucine-OH and l-prolyl-l-N-methylphenylalanine-OMe. A coupling reaction was accomplished utilizing N,N′-Dicyclo...

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Bibliographic Details
Main Authors: Rajiv Dahiya, Suresh Kumar, Sukhbir Lal Khokra, Sheeba Varghese Gupta, Vijaykumar B. Sutariya, Deepak Bhatia, Ajay Sharma, Shamjeet Singh, Sandeep Maharaj
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Marine Drugs
Subjects:
N-methylation
tetracyclopeptide
Pseudomonas sp.
macrocyclization
marine sponge
Pseudoalteromonas sp.
solution-phase peptide synthesis
pharmacological activity
Online Access:http://www.mdpi.com/1660-3397/16/9/305

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http://www.mdpi.com/1660-3397/16/9/305

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