Temporal Alterations in Mitochondrial β-Oxidation and Oxidative Stress Aggravate Chronic Kidney Disease Development in 5/6 Nephrectomy Induced Renal Damage

Temporal Alterations in Mitochondrial β-Oxidation and Oxidative Stress Aggravate Chronic Kidney Disease Development in 5/6 Nephrectomy Induced Renal Damage

Five-sixths nephrectomy (5/6Nx) model is widely used for studying the mechanisms involved in chronic kidney disease (CKD) progression, a kidney pathology that has increased dramatically in recent years. Mitochondrial impairment is a key mechanism that aggravates CKD progression; however, the informa...

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Bibliographic Details
Main Authors: Omar Emiliano Aparicio-Trejo, Pedro Rojas-Morales, Sabino Hazael Avila-Rojas, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Alexis Paulina Jiménez-Uribe, Rodrigo Prieto-Carrasco, Laura Gabriela Sánchez-Lozada, José Pedraza-Chaverri, Edilia Tapia
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
chronic kidney disease
5/6 nephrectomy
β-oxidation impairment
mitochondrial damage
Online Access:https://www.mdpi.com/1422-0067/21/18/6512

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