The nuclear import of the transcription factor MyoD is reduced in mesenchymal stem cells grown in a 3D micro-engineered niche

The nuclear import of the transcription factor MyoD is reduced in mesenchymal stem cells grown in a 3D micro-engineered niche

Abstract Smart biomaterials are increasingly being used to control stem cell fate in vitro by the recapitulation of the native niche microenvironment. By integrating experimental measurements with numerical models, we show that in mesenchymal stem cells grown inside a 3D synthetic niche both nuclear...

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Bibliographic Details
Main Authors: Emanuela Jacchetti, Ramin Nasehi, Lucia Boeri, Valentina Parodi, Alessandro Negro, Diego Albani, Roberto Osellame, Giulio Cerullo, Jose Felix Rodriguez Matas, Manuela Teresa Raimondi
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81920-2

Internet

https://doi.org/10.1038/s41598-021-81920-2

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