Assessing Suitability of Co@Au Core/Shell Nanoparticle Geometry for Improved Theranostics in Colon Carcinoma
The interactions between cells and nanomaterials at the nanoscale play a pivotal role in controlling cellular behavior and ample evidence links cell intercommunication to nanomaterial size. However, little is known about the effect of nanomaterial geometry on cell behavior. To elucidate this and to...
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doaj-f588bae959e849ee86accecd4ae967e22021-08-26T14:09:18ZengMDPI AGNanomaterials2079-49912021-08-01112048204810.3390/nano11082048Assessing Suitability of Co@Au Core/Shell Nanoparticle Geometry for Improved Theranostics in Colon CarcinomaUdesh Dhawan0Ching-Li Tseng1Huey-Yuan Wang2Shin-Yun Hsu3Meng-Tsan Tsai4Ren-Jei Chung5Institute of Chemistry, Academia Sinica, 128, Sec. 2, Academia Rd., Taipei 11529, TaiwanGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, 250, Wu-Hsing St., Taipei 11031, TaiwanDepartment of Stomatology, MacKay Memorial Hospital, 92, Sec. 2, Zhongshan N. Rd., Taipei 10449, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), 1, Sec. 3, Zhongxiao E. Rd., Taipei 10608, TaiwanDepartment of Electrical Engineering, Chang Gung University, 259, Wenhua 1st Rd., Taoyuan City 33302, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), 1, Sec. 3, Zhongxiao E. Rd., Taipei 10608, TaiwanThe interactions between cells and nanomaterials at the nanoscale play a pivotal role in controlling cellular behavior and ample evidence links cell intercommunication to nanomaterial size. However, little is known about the effect of nanomaterial geometry on cell behavior. To elucidate this and to extend the application in cancer theranostics, we have engineered core–shell cobalt–gold nanoparticles with spherical (Co@Au NPs) and elliptical morphology (Co@Au NEs). Our results show that owing to superparamagnetism, Co@Au NPs can generate hyperthermia upon magnetic field stimulation. In contrast, due to the geometric difference, Co@Au NEs can be optically excited to generate hyperthermia upon photostimulation and elevate the medium temperature to 45 °C. Both nanomaterial geometries can be employed as prospective contrast agents; however, at identical concentration, Co@Au NPs exhibited 4-fold higher cytotoxicity to L929 fibroblasts as compared to Co@Au NEs, confirming the effect of nanomaterial geometry on cell fate. Furthermore, photostimulation-generated hyperthermia prompted detachment of anti-cancer drug, Methotrexate (MTX), from Co@Au NEs-MTX complex and which triggered 90% decrease in SW620 colon carcinoma cell viability, confirming their application in cancer theranostics. The geometry-based perturbation of cell fate can have a profound impact on our understanding of interactions at nano-bio interface which can be exploited for engineering materials with optimized geometries for superior theranostic applications.https://www.mdpi.com/2079-4991/11/8/2048core–shellcobalt–goldnanoparticleshyperthermiamethotrexatecolon carcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Udesh Dhawan Ching-Li Tseng Huey-Yuan Wang Shin-Yun Hsu Meng-Tsan Tsai Ren-Jei Chung |
spellingShingle |
Udesh Dhawan Ching-Li Tseng Huey-Yuan Wang Shin-Yun Hsu Meng-Tsan Tsai Ren-Jei Chung Assessing Suitability of Co@Au Core/Shell Nanoparticle Geometry for Improved Theranostics in Colon Carcinoma Nanomaterials core–shell cobalt–gold nanoparticles hyperthermia methotrexate colon carcinoma |
author_facet |
Udesh Dhawan Ching-Li Tseng Huey-Yuan Wang Shin-Yun Hsu Meng-Tsan Tsai Ren-Jei Chung |
author_sort |
Udesh Dhawan |
title |
Assessing Suitability of Co@Au Core/Shell Nanoparticle Geometry for Improved Theranostics in Colon Carcinoma |
title_short |
Assessing Suitability of Co@Au Core/Shell Nanoparticle Geometry for Improved Theranostics in Colon Carcinoma |
title_full |
Assessing Suitability of Co@Au Core/Shell Nanoparticle Geometry for Improved Theranostics in Colon Carcinoma |
title_fullStr |
Assessing Suitability of Co@Au Core/Shell Nanoparticle Geometry for Improved Theranostics in Colon Carcinoma |
title_full_unstemmed |
Assessing Suitability of Co@Au Core/Shell Nanoparticle Geometry for Improved Theranostics in Colon Carcinoma |
title_sort |
assessing suitability of co@au core/shell nanoparticle geometry for improved theranostics in colon carcinoma |
publisher |
MDPI AG |
series |
Nanomaterials |
issn |
2079-4991 |
publishDate |
2021-08-01 |
description |
The interactions between cells and nanomaterials at the nanoscale play a pivotal role in controlling cellular behavior and ample evidence links cell intercommunication to nanomaterial size. However, little is known about the effect of nanomaterial geometry on cell behavior. To elucidate this and to extend the application in cancer theranostics, we have engineered core–shell cobalt–gold nanoparticles with spherical (Co@Au NPs) and elliptical morphology (Co@Au NEs). Our results show that owing to superparamagnetism, Co@Au NPs can generate hyperthermia upon magnetic field stimulation. In contrast, due to the geometric difference, Co@Au NEs can be optically excited to generate hyperthermia upon photostimulation and elevate the medium temperature to 45 °C. Both nanomaterial geometries can be employed as prospective contrast agents; however, at identical concentration, Co@Au NPs exhibited 4-fold higher cytotoxicity to L929 fibroblasts as compared to Co@Au NEs, confirming the effect of nanomaterial geometry on cell fate. Furthermore, photostimulation-generated hyperthermia prompted detachment of anti-cancer drug, Methotrexate (MTX), from Co@Au NEs-MTX complex and which triggered 90% decrease in SW620 colon carcinoma cell viability, confirming their application in cancer theranostics. The geometry-based perturbation of cell fate can have a profound impact on our understanding of interactions at nano-bio interface which can be exploited for engineering materials with optimized geometries for superior theranostic applications. |
topic |
core–shell cobalt–gold nanoparticles hyperthermia methotrexate colon carcinoma |
url |
https://www.mdpi.com/2079-4991/11/8/2048 |
work_keys_str_mv |
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