More Than Just Simple Interaction between STIM and Orai Proteins: CRAC Channel Function Enabled by a Network of Interactions with Regulatory Proteins

More Than Just Simple Interaction between STIM and Orai Proteins: CRAC Channel Function Enabled by a Network of Interactions with Regulatory Proteins

The calcium-release-activated calcium (CRAC) channel, activated by the release of Ca<sup>2+</sup> from the endoplasmic reticulum (ER), is critical for Ca<sup>2+</sup> homeostasis and active signal transduction in a plethora of cell types. Spurred by the long-sought decryption...

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Bibliographic Details
Main Authors: Sascha Berlansky, Christina Humer, Matthias Sallinger, Irene Frischauf
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
Ca<sup>2+</sup>
SOCE
CRAC
STIM1
Orai1
positive/negative modulators of CRAC channel activation
Online Access:https://www.mdpi.com/1422-0067/22/1/471

Internet

https://www.mdpi.com/1422-0067/22/1/471

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