High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domain.

Monoclonal and recombinant antibodies are ubiquitous tools in diagnostics, therapeutics, and biotechnology. However, their biochemical properties lack optimal robustness, their bacterial production is not easy, and possibilities to create multifunctional fusion proteins based on them are limited. Mo...

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Bibliographic Details
Main Authors: Annika Järviluoma, Tomas Strandin, Sebastian Lülf, Jérôme Bouchet, Anna R Mäkelä, Matthias Geyer, Serge Benichou, Kalle Saksela
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792285/?tool=EBI