mTOR Promotes Tissue Factor Expression and Activity in EGFR-Mutant Cancer

mTOR Promotes Tissue Factor Expression and Activity in EGFR-Mutant Cancer

Mechanistic target of rapamycin (mTOR) signaling pathway mediates the function of oncogenic receptor tyrosine kinases (RTKs). We aimed to elucidate new role of mTOR in EGFR-mutant (EGFR-mut) non-small cell lung cancer (NSCLC) and glioblastoma (GBM) with a focus on tumor microenvironments. Here, we r...

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Bibliographic Details
Main Authors: Ying Cong, Qingrou Li, Xuesai Zhang, Yaqing Chen, Ker Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
mTOR inhibitor
tissue factor
tumor microenvironment
EGFR mutant cancer
mTOR-TF axis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01615/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01615/full

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