Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder.

Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder.

In the rodent forebrain GABAergic neurons are generated from progenitor cells that express the transcription factors Dlx1 and Dlx2. The Rap-1 guanine nucleotide exchange factor, MR-GEF, is turned on by many of these developing GABAergic neurons. Expression of both Dlx1/2 and MR-GEF is retained in bo...

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Bibliographic Details
Main Authors: Angela Bithell, Tony Hsu, Apsara Kandanearatchi, Sabine Landau, Ian P Everall, Ming T Tsuang, Gursharan Chana, Brenda P Williams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2861006?pdf=render

Internet

http://europepmc.org/articles/PMC2861006?pdf=render

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