Endothelial Phosphatase VE-PTP Participates in Vasculogenic Mimicry by Preventing Autophagic Degradation of VE-Cadherin

Endothelial Phosphatase VE-PTP Participates in Vasculogenic Mimicry by Preventing Autophagic Degradation of VE-Cadherin

Aberrant extra-vascular expression of VE-cadherin has been observed in metastasis associated with Vasculogenic Mimicry (VM); we have recently shown that in VM prone cells VE-cadherin is mainly in the form of phospho-VE-cadherin in Y658 allowing increased plasticity that potentiates VM development in...

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Bibliographic Details
Main Authors: Daniel Delgado-Bellido, Concepción Bueno-Galera, Laura López-Jiménez, Angel Garcia-Diaz, F. Javier Oliver
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
vasculogenic mimicry (VM)
VE-PTP
vascular endothelial receptor protein tyrosine phosphatase
VE-cadherin
melanoma
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00018/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00018/full

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