Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice
Abstract Background Colitis is a well-known subtype of inflammatory bowel disease and is caused by diverse factors. Previous research has shown that KIOM-MA elicits anti-inflammatory and anti-allergic effects on various diseases. KIOM-MA-128, our novel herbal formula, was generated from KIOM-MA usin...
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doaj-f6d2acdc7a034b1485053c0d3016c9f02020-11-25T02:19:37ZengBMCBMC Complementary and Alternative Medicine1472-68822017-07-011711710.1186/s12906-017-1855-4Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in miceDong-Gun Kim0Mi-Ra Lee1Jae-Myung Yoo2Kwang-Il Park3Jin-Yeul Ma4Korea Medicine (KM)-Application Center, Korea Institute of Oriental MedicineKorea Medicine (KM)-Application Center, Korea Institute of Oriental MedicineKorea Medicine (KM)-Application Center, Korea Institute of Oriental MedicineKorea Medicine (KM)-Application Center, Korea Institute of Oriental MedicineKorea Medicine (KM)-Application Center, Korea Institute of Oriental MedicineAbstract Background Colitis is a well-known subtype of inflammatory bowel disease and is caused by diverse factors. Previous research has shown that KIOM-MA elicits anti-inflammatory and anti-allergic effects on various diseases. KIOM-MA-128, our novel herbal formula, was generated from KIOM-MA using probiotics to improve the therapeutic efficacy. We investigated whether KIOM-MA-128 has protective activity in a mouse model of acute colitis induced by dextran sodium sulfate (DSS). Methods Colitis was induced by DSS administered to ICR mice in drinking water. KIOM-MA-128 (125 or 250 mg/kg) was orally administered once per day. The body weights of the mice were measured daily, and colonic endoscopies were performed at 5 and 8 days. Colon length as well as histological and cytokine changes were observed at the end of drug administration. Results KIOM-MA-128 has pharmacological activity in an acute colitis model. KIOM-MA-128 reduced the loss of body weight and disease activity index (DAI) and inhibited the abnormally short colon lengths and the colonic damage in this mouse model of acute colitis. Moreover, KIOM-MA-128 suppressed pro-inflammatory cytokine expression and maintained the integrity of the tight junctions during DSS-induced colitis. Conclusion The results indicated that KIOM-MA-128 protects against DSS-induced colitis in mice and suggested that this formula might be a candidate treatment for inflammatory bowel disease (IBD).http://link.springer.com/article/10.1186/s12906-017-1855-4Ulcerative colitisHerbal medicineInflammationTight junctionColonKIOM-MA-128 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dong-Gun Kim Mi-Ra Lee Jae-Myung Yoo Kwang-Il Park Jin-Yeul Ma |
spellingShingle |
Dong-Gun Kim Mi-Ra Lee Jae-Myung Yoo Kwang-Il Park Jin-Yeul Ma Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice BMC Complementary and Alternative Medicine Ulcerative colitis Herbal medicine Inflammation Tight junction Colon KIOM-MA-128 |
author_facet |
Dong-Gun Kim Mi-Ra Lee Jae-Myung Yoo Kwang-Il Park Jin-Yeul Ma |
author_sort |
Dong-Gun Kim |
title |
Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice |
title_short |
Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice |
title_full |
Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice |
title_fullStr |
Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice |
title_full_unstemmed |
Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice |
title_sort |
fermented herbal formula kiom-ma-128 protects against acute colitis induced by dextran sodium sulfate in mice |
publisher |
BMC |
series |
BMC Complementary and Alternative Medicine |
issn |
1472-6882 |
publishDate |
2017-07-01 |
description |
Abstract Background Colitis is a well-known subtype of inflammatory bowel disease and is caused by diverse factors. Previous research has shown that KIOM-MA elicits anti-inflammatory and anti-allergic effects on various diseases. KIOM-MA-128, our novel herbal formula, was generated from KIOM-MA using probiotics to improve the therapeutic efficacy. We investigated whether KIOM-MA-128 has protective activity in a mouse model of acute colitis induced by dextran sodium sulfate (DSS). Methods Colitis was induced by DSS administered to ICR mice in drinking water. KIOM-MA-128 (125 or 250 mg/kg) was orally administered once per day. The body weights of the mice were measured daily, and colonic endoscopies were performed at 5 and 8 days. Colon length as well as histological and cytokine changes were observed at the end of drug administration. Results KIOM-MA-128 has pharmacological activity in an acute colitis model. KIOM-MA-128 reduced the loss of body weight and disease activity index (DAI) and inhibited the abnormally short colon lengths and the colonic damage in this mouse model of acute colitis. Moreover, KIOM-MA-128 suppressed pro-inflammatory cytokine expression and maintained the integrity of the tight junctions during DSS-induced colitis. Conclusion The results indicated that KIOM-MA-128 protects against DSS-induced colitis in mice and suggested that this formula might be a candidate treatment for inflammatory bowel disease (IBD). |
topic |
Ulcerative colitis Herbal medicine Inflammation Tight junction Colon KIOM-MA-128 |
url |
http://link.springer.com/article/10.1186/s12906-017-1855-4 |
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