COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B

We investigated Nucleos(t)ide-analogue (NA)-resistance mutations (mt) in 142 treatment-naive children with Chronic Hepatitis B (CHB), using a sensitive co-amplification at lower denaturation temperature (COLD)-PCR with Sanger DNA sequencing. An NA resistance-associated mt in the hepatitis B virus (H...

Full description

Bibliographic Details
Main Authors: Thuy Thi Bich Phung, Son Van Chu, Son Thien Vu, Hanh Thi Pham, Hang Minh Nguyen, Hoan Dang Nguyen, Ngan Thi Le, Dung Van Nguyen, Phuong Thai Truong, Van Thi Tuong Vu, Anh Thi Van Nguyen
Format: Article
Published: MDPI AG 2020-07-01
Online Access: