Automated Sputum Cytometry for Detection of Intraepithelial Neoplasias in the Lung

Automated Sputum Cytometry for Detection of Intraepithelial Neoplasias in the Lung

Background: Despite the benefits of early lung cancer detection, no effective strategy for early screening and treatment exists, partly due to a lack of effective surrogate biomarkers. Our novel sputum biomarker, the Combined Score (CS), uses automated image cytometric analysis of ploidy and nuclear...

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Bibliographic Details
Main Authors: Gerald Li, Martial Guillaud, Jean LeRiche, Annette McWilliams, Adi Gazdar, Stephen Lam, Calum MacAulay
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Analytical Cellular Pathology
Online Access:http://dx.doi.org/10.3233/ACP-2012-0053
Description
Summary:Background: Despite the benefits of early lung cancer detection, no effective strategy for early screening and treatment exists, partly due to a lack of effective surrogate biomarkers. Our novel sputum biomarker, the Combined Score (CS), uses automated image cytometric analysis of ploidy and nuclear morphology to detect subtle intraepithelial changes that often precede lung tumours.
ISSN:2210-7177
2210-7185

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