Breast cancer susceptibility protein 1 (BRCA1) rescues neurons from cerebral ischemia/reperfusion injury through NRF2-mediated antioxidant pathway

Breast cancer susceptibility protein 1 (BRCA1) rescues neurons from cerebral ischemia/reperfusion injury through NRF2-mediated antioxidant pathway

Cellular oxidative stress plays a vital role in the pathological process of neural damage in cerebral ischemia/reperfusion (I/R). The breast cancer susceptibility protein 1 (BRCA1), a tumor suppressor, can modulate cellular antioxidant response and DNA repair. Yet the role of BRCA1 in cerebral I/R i...

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Bibliographic Details
Main Authors: Pengfei Xu, Qian Liu, Yi Xie, Xiaolei Shi, Yunzi Li, Mengna Peng, Hongquan Guo, Rui Sun, Juanji Li, Ye Hong, Xinfeng Liu, Gelin Xu
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718304737

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http://www.sciencedirect.com/science/article/pii/S2213231718304737

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