Systems biology approaches in the study of Chinese herbal formulae
Abstract Systems biology is an academic field that attempts to integrate different levels of information to understand how biological systems function. It is the study of the composition of all components of a biological system and their interactions under specific conditions. The core of systems bi...
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doaj-f87bfa4dfdaa4a9a99b524117a86092a2020-11-25T00:14:27ZengBMCChinese Medicine1749-85462018-12-0113111010.1186/s13020-018-0221-xSystems biology approaches in the study of Chinese herbal formulaeFei-Fei Cai0Wen-Jun Zhou1Rong Wu2Shi-Bing Su3Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese MedicineResearch Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese MedicineResearch Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese MedicineResearch Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese MedicineAbstract Systems biology is an academic field that attempts to integrate different levels of information to understand how biological systems function. It is the study of the composition of all components of a biological system and their interactions under specific conditions. The core of systems biology is holistic and systematic research, which is different from the manner of thinking and research of all other branches of biology to date. Chinese herbal formulae (CHF) are the main form of Chinese medicine and are composed of single Chinese herbal medicines (CHMs) with pharmacological and pharmacodynamic compatibility. When single CHMs are combined into CHF, the result is different from the original effect of a single drug and can be better adapted to more diseases with complex symptoms. CHF represent a complex system with multiple components, targets and effects. Therefore, the use of systems biology is conducive to revealing the complex characteristics of CHF. With the rapid development of omics technologies, systems biology has been widely and increasingly applied to the study of the basis of the pharmacological substances, action targets and mechanisms of CHF. To meet the challenges of multiomics synthesis-intensive studies and system dynamics research in CHF, this paper reviews the common techniques of genomics, transcriptomics, proteomics, metabolomics, and metagenomics and their applications in research on CHF.http://link.springer.com/article/10.1186/s13020-018-0221-xSystems biologyChinese herbal formulaeChinese medicineOmics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fei-Fei Cai Wen-Jun Zhou Rong Wu Shi-Bing Su |
spellingShingle |
Fei-Fei Cai Wen-Jun Zhou Rong Wu Shi-Bing Su Systems biology approaches in the study of Chinese herbal formulae Chinese Medicine Systems biology Chinese herbal formulae Chinese medicine Omics |
author_facet |
Fei-Fei Cai Wen-Jun Zhou Rong Wu Shi-Bing Su |
author_sort |
Fei-Fei Cai |
title |
Systems biology approaches in the study of Chinese herbal formulae |
title_short |
Systems biology approaches in the study of Chinese herbal formulae |
title_full |
Systems biology approaches in the study of Chinese herbal formulae |
title_fullStr |
Systems biology approaches in the study of Chinese herbal formulae |
title_full_unstemmed |
Systems biology approaches in the study of Chinese herbal formulae |
title_sort |
systems biology approaches in the study of chinese herbal formulae |
publisher |
BMC |
series |
Chinese Medicine |
issn |
1749-8546 |
publishDate |
2018-12-01 |
description |
Abstract Systems biology is an academic field that attempts to integrate different levels of information to understand how biological systems function. It is the study of the composition of all components of a biological system and their interactions under specific conditions. The core of systems biology is holistic and systematic research, which is different from the manner of thinking and research of all other branches of biology to date. Chinese herbal formulae (CHF) are the main form of Chinese medicine and are composed of single Chinese herbal medicines (CHMs) with pharmacological and pharmacodynamic compatibility. When single CHMs are combined into CHF, the result is different from the original effect of a single drug and can be better adapted to more diseases with complex symptoms. CHF represent a complex system with multiple components, targets and effects. Therefore, the use of systems biology is conducive to revealing the complex characteristics of CHF. With the rapid development of omics technologies, systems biology has been widely and increasingly applied to the study of the basis of the pharmacological substances, action targets and mechanisms of CHF. To meet the challenges of multiomics synthesis-intensive studies and system dynamics research in CHF, this paper reviews the common techniques of genomics, transcriptomics, proteomics, metabolomics, and metagenomics and their applications in research on CHF. |
topic |
Systems biology Chinese herbal formulae Chinese medicine Omics |
url |
http://link.springer.com/article/10.1186/s13020-018-0221-x |
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