A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers

Currently, gut microbiome profiling largely relies on next-generation sequencing, which is slow and expensive. Here, the authors develop a low-cost, paper-based synthetic biology platform that allows species-specific quantification of bacterial mRNAs and clinically relevant host biomarkers.

Bibliographic Details
Main Authors:	Melissa K. Takahashi, Xiao Tan, Aaron J. Dy, Dana Braff, Reid T. Akana, Yoshikazu Furuta, Nina Donghia, Ashwin Ananthakrishnan, James J. Collins
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05864-4

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spelling	doaj-f8dae91102924721b1ee437d07c154802021-05-11T09:53:24ZengNature Publishing GroupNature Communications2041-17232018-08-019111210.1038/s41467-018-05864-4A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkersMelissa K. Takahashi0Xiao Tan1Aaron J. Dy2Dana Braff3Reid T. Akana4Yoshikazu Furuta5Nina Donghia6Ashwin Ananthakrishnan7James J. Collins8Institute for Medical Engineering and Science, Massachusetts Institute of TechnologyInstitute for Medical Engineering and Science, Massachusetts Institute of TechnologyInstitute for Medical Engineering and Science, Massachusetts Institute of TechnologyInstitute for Medical Engineering and Science, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyInstitute for Medical Engineering and Science, Massachusetts Institute of TechnologyWyss Institute for Biologically Inspired Engineering, Harvard UniversityDivision of Gastroenterology, Massachusetts General HospitalInstitute for Medical Engineering and Science, Massachusetts Institute of TechnologyCurrently, gut microbiome profiling largely relies on next-generation sequencing, which is slow and expensive. Here, the authors develop a low-cost, paper-based synthetic biology platform that allows species-specific quantification of bacterial mRNAs and clinically relevant host biomarkers.https://doi.org/10.1038/s41467-018-05864-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Melissa K. Takahashi Xiao Tan Aaron J. Dy Dana Braff Reid T. Akana Yoshikazu Furuta Nina Donghia Ashwin Ananthakrishnan James J. Collins
spellingShingle	Melissa K. Takahashi Xiao Tan Aaron J. Dy Dana Braff Reid T. Akana Yoshikazu Furuta Nina Donghia Ashwin Ananthakrishnan James J. Collins A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers Nature Communications
author_facet	Melissa K. Takahashi Xiao Tan Aaron J. Dy Dana Braff Reid T. Akana Yoshikazu Furuta Nina Donghia Ashwin Ananthakrishnan James J. Collins
author_sort	Melissa K. Takahashi
title	A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers
title_short	A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers
title_full	A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers
title_fullStr	A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers
title_full_unstemmed	A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers
title_sort	low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-08-01
description	Currently, gut microbiome profiling largely relies on next-generation sequencing, which is slow and expensive. Here, the authors develop a low-cost, paper-based synthetic biology platform that allows species-specific quantification of bacterial mRNAs and clinically relevant host biomarkers.
url	https://doi.org/10.1038/s41467-018-05864-4
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A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers

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